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Original Article
Abnormal spontaneous brain activities in breast cancer patients after EC-T chemotherapy: A resting-state functional magnetic resonance imaging study
FENG Wei  LIU Tonghui  LI Peng  WANG Xueyuan  CHEN Rui  ZHANG Huawen  NING Long 

Cite this article as: Feng W, Liu TH, Li P, et al. Abnormal spontaneous brain activities in breast cancer patients after EC-T chemotherapy: A resting-state functional magnetic resonance imaging study[J]. Chin J Magn Reson Imaging, 2022, 13(6): 56-60. DOI:10.12015/issn.1674-8034.2022.06.011.


[Abstract] Objective Using resting-state functional magnetic imaging (rs-fMRI) and amplitude of low frequency fluctuation (ALFF) algorithm to investigate the abnormal spontaneous brain activities and related cognitive dysfunction in breast cancer patients after chemotherapy.Materials and Methods We selected twenty-nine patients with invasive ductal carcinoma of the breast (patients group) confirmed by pathology. All patients were female and all received standard EC-T (E: Epirubicin; C: Cyclophosphamide; T: Paclitaxel) sequential chemotherapy. Thirty age- and education level matched female healthy volunteers (controls group) were selected during the same period. All subjects first underwent Montreal Cognitive Assessment (MoCA) and Auditory Verbal Learning Test-Huashan version (AVLT-H), 3D brain volume imaging and rs-fMRI scans. Finally, the DPARSF software package was used for processing and statistical analysis. The SPSS 19.0 software package was used for statistical analysis of clinical data and scales.Results The MoCA scores of the patients group were lower than controls group (P=0.002). There was no significant difference in the scores of each sub-item of AVLT-H between-group (P>0.05). The ALFF values of left dorsolateral superior frontal gyrus (Frontal_Sup_L) in the Patients group were higher than controls group (P<0.001), whereas the ALFF values of cerebellar vermis_6 (Vermis_6) and left lateral cingulate gyrus (Cingulum_Ant_L) were lower than the controls group (P<0.001). Pearson correlation analysis showed that the ALFF values of the left lateral cingulate gyrus were significantly positive correlated with the MoCA score (r=0.789, P<0.001).Conclusions Patients with breast invasive ductal carcinoma after EC-T chemotherapy have global cognitive dysfunction. Spontaneous neural activity abnormalities in key brain regions are closely related to the overall cognitive impairment. Spontaneous brain activity abnormalities in these regions are expected to become imaging markers for monitoring and treatment of breast cancer patients' cognitive dysfunction after EC-T chemotherapy.
[Keywords] breast cancer;cognitive dysfunction;chemotherapy;amplitude of low frequency fluctuation;resting-state functional magnetic resonance imaging

FENG Wei   LIU Tonghui   LI Peng   WANG Xueyuan   CHEN Rui   ZHANG Huawen   NING Long*  

Department of Medical Imaging, 215 Hospital of Shaanxi Nuclear Industry, Xianyang 712001, China

Ning L, E-mail: 254431957@qq.com

Conflicts of interest   None.

Received  2021-10-20
Accepted  2022-04-13
DOI: 10.12015/issn.1674-8034.2022.06.011
Cite this article as: Feng W, Liu TH, Li P, et al. Abnormal spontaneous brain activities in breast cancer patients after EC-T chemotherapy: A resting-state functional magnetic resonance imaging study[J]. Chin J Magn Reson Imaging, 2022, 13(6): 56-60.DOI:10.12015/issn.1674-8034.2022.06.011

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