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Original Article
Changes in voxel-mirrored homotopic connectivity of bilateral cuneus after acupuncture in migraine without aura patients
ZHANG Yanan  LIU Lu  ZHANG Yajie  LIU Dapeng  LIU Ni  WANG Zhenjia  WANG Linpeng  HUO Jianwei 

Cite this article as: Zhang YN, Liu L, Zhang YJ, et al. Changes in voxel-mirrored homotopic connectivity of bilateral cuneus after acupuncture in migraine without aura patients[J]. Chin J Magn Reson Imaging, 2022, 13(6): 50-55. DOI:10.12015/issn.1674-8034.2022.06.010.

[Abstract] Objective To investigate whether interictal voxel-mirrored homotopic connectivity (VMHC) was impaired in migraine without aura (MwoA) patients, and how did VMHC change after acupuncture treatment.Materials and Methods Fifty-four MwoA patients and matched forty-four healthy controls were recruited into this study. Patients underwent a four-week acupuncture treatment, whereas controls didn't have any therapy. Functional magnetic resonance imaging data and clinical information were acquired at baseline and after treatment. The VMHC analysis method was used to compare the difference between two groups at baseline and in MwoA patients before and after treatment. Furthermore, correlation analysis was conducted to explore the relationship between VMHC changes of brain regions modulated by acupuncture treatment and improvement in clinical scores.Results Compared with healthy controls, MwoA patients revealed significantly decreased VMHC in the bilateral cerebellum_Ⅷ, cuneus and postcentral gyrus (voxel level P<0.001,cluster level P<0.05). After acupuncture treatment, the clinical indicators of migraine patients were significantly improved, and resting-state functional magnetic resonance imaging showed that weakened VMHC of the bilateral cuneus remarkably enhanced (voxel level P<0.001, cluster level P<0.05). The change of VMHC in the bilateral cuneus was positively correlated with change of self-rating anxiety scale scores (r=0.291, P<0.05).Conclusions Impaired VMHC in the bilateral cerebellum, visual cortex and primary somatosensory cortex may be involved in the central mechanism of MwoA during interictal period. Acupuncture treatment had significant clinical efficacy for migraine, and could enhance weaken VMHC in the bilateral cuneus.
[Keywords] migraine without aura;interictal period;acupuncture;functional magnetic resonance imaging;voxel-mirrored homotopic connectivity

ZHANG Yanan1   LIU Lu2   ZHANG Yajie3   LIU Dapeng4   LIU Ni1   WANG Zhenjia1   WANG Linpeng2   HUO Jianwei1*  

1 Department of Radiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China

2 Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China

3 Department of Acupuncture and Moxibustion, Shanxi Hospital of Integrated Traditional and Western Medicine, Taiyuan 030001, China

4 Department of Acupuncture and Moxibustion, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China

Huo JW, E-mail:

Conflicts of interest   None.

Received  2022-03-22
Accepted  2022-05-31
DOI: 10.12015/issn.1674-8034.2022.06.010
Cite this article as: Zhang YN, Liu L, Zhang YJ, et al. Changes in voxel-mirrored homotopic connectivity of bilateral cuneus after acupuncture in migraine without aura patients[J]. Chin J Magn Reson Imaging, 2022, 13(6): 50-55.DOI:10.12015/issn.1674-8034.2022.06.010

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