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Original Article
Changes in voxel-mirrored homotopic connectivity of bilateral cuneus after acupuncture in migraine without aura patients
ZHANG Yanan  LIU Lu  ZHANG Yajie  LIU Dapeng  LIU Ni  WANG Zhenjia  WANG Linpeng  HUO Jianwei 

Cite this article as: Zhang YN, Liu L, Zhang YJ, et al. Changes in voxel-mirrored homotopic connectivity of bilateral cuneus after acupuncture in migraine without aura patients[J]. Chin J Magn Reson Imaging, 2022, 13(6): 50-55. DOI:10.12015/issn.1674-8034.2022.06.010.


[Abstract] Objective To investigate whether interictal voxel-mirrored homotopic connectivity (VMHC) was impaired in migraine without aura (MwoA) patients, and how did VMHC change after acupuncture treatment.Materials and Methods Fifty-four MwoA patients and matched forty-four healthy controls were recruited into this study. Patients underwent a four-week acupuncture treatment, whereas controls didn't have any therapy. Functional magnetic resonance imaging data and clinical information were acquired at baseline and after treatment. The VMHC analysis method was used to compare the difference between two groups at baseline and in MwoA patients before and after treatment. Furthermore, correlation analysis was conducted to explore the relationship between VMHC changes of brain regions modulated by acupuncture treatment and improvement in clinical scores.Results Compared with healthy controls, MwoA patients revealed significantly decreased VMHC in the bilateral cerebellum_Ⅷ, cuneus and postcentral gyrus (voxel level P<0.001,cluster level P<0.05). After acupuncture treatment, the clinical indicators of migraine patients were significantly improved, and resting-state functional magnetic resonance imaging showed that weakened VMHC of the bilateral cuneus remarkably enhanced (voxel level P<0.001, cluster level P<0.05). The change of VMHC in the bilateral cuneus was positively correlated with change of self-rating anxiety scale scores (r=0.291, P<0.05).Conclusions Impaired VMHC in the bilateral cerebellum, visual cortex and primary somatosensory cortex may be involved in the central mechanism of MwoA during interictal period. Acupuncture treatment had significant clinical efficacy for migraine, and could enhance weaken VMHC in the bilateral cuneus.
[Keywords] migraine without aura;interictal period;acupuncture;functional magnetic resonance imaging;voxel-mirrored homotopic connectivity

ZHANG Yanan1   LIU Lu2   ZHANG Yajie3   LIU Dapeng4   LIU Ni1   WANG Zhenjia1   WANG Linpeng2   HUO Jianwei1*  

1 Department of Radiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China

2 Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China

3 Department of Acupuncture and Moxibustion, Shanxi Hospital of Integrated Traditional and Western Medicine, Taiyuan 030001, China

4 Department of Acupuncture and Moxibustion, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China

Huo JW, E-mail: huojianwei@bjzhongyi.com

Conflicts of interest   None.

Received  2022-03-22
Accepted  2022-05-31
DOI: 10.12015/issn.1674-8034.2022.06.010
Cite this article as: Zhang YN, Liu L, Zhang YJ, et al. Changes in voxel-mirrored homotopic connectivity of bilateral cuneus after acupuncture in migraine without aura patients[J]. Chin J Magn Reson Imaging, 2022, 13(6): 50-55.DOI:10.12015/issn.1674-8034.2022.06.010

[1]
Olesen J. Problem areas in the International Classification of Headache Disorders, 3rd edition (beta)[J]. Cephalalgia, 2014, 34: 1193-1199. DOI: 10.1177/0333102414534327.
[2]
GBD Headache Collaborators. Global, regional, and national burden of migraine and tension-type headache, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016[J]. Lancet Neurol, 2018, 17(11): 954-976. DOI: 10.1016/S1474-4422(18)30322-3.
[3]
Harris L, L'Italien G, Kumar A, et al. Real-world assessment of the relationship between migraine-related disability and healthcare costs in the United States[J]. Headache, 2022, 62(4): 473-481. DOI: 10.1111/head.14289.
[4]
Zhang XT, Li XY, Zhao C, et al. An overview of systematic reviews of randomized controlled trials on acupuncture treating migraine[J]. Pain Res Manag, 2019, 2019: 5930627. DOI: 10.1155/2019/5930627.
[5]
Pan BJ. Effect of acupuncture on pain degree and quality of life in migraine patients[J]. Heilongjiang J Tradit Chin Med, 2021, 50(2): 132-133.
[6]
Lu TT, Lu CC, Li MX, et al. Reporting and methodological quality of meta-analyses of acupuncture for patients with migraine: a methodological investigation with evidence map[J]. J Integr Med, 2022, 20(3): 213-220. DOI: 10.1016/j.joim.2022.02.003.
[7]
Linde K, Allais G, Brinkhaus B, et al. Acupuncture for migraine prophylaxis[J]. Cochrane Database Syst Rev, 2009(1): CD001218. DOI: 10.1002/14651858.CD001218.pub2.
[8]
Zuo XN, Kelly C, di Martino A, et al. Growing together and growing apart: regional and sex differences in the lifespan developmental trajectories of functional homotopy[J]. J Neurosci, 2010, 30(45): 15034-15043. DOI: 10.1523/JNEUROSCI.2612-10.2010.
[9]
Yuan K, Qin W, Liu P, et al. Reduced fractional anisotropy of corpus callosum modulates inter-hemispheric resting state functional connectivity in migraine patients without aura[J]. PLoS One, 2012, 7(9): e45476. DOI: 10.1371/journal.pone.0045476.
[10]
Zhang SF, Xue Y, Jiang QJ, et al. A resting-state fMRI study of inter-hemisphere voxel-mirrored homotopic connectivity in patients with menstrual migraine[J]. Chin J Med Imaging Technol, 2018, 34(7): 980-984. DOI: 10.13929/j.1003-3289.201712079.
[11]
Cao ZM, Chen YC, Liu GY, et al. Abnormalities of thalamic functional connectivity in patients with migraine: a resting-state fMRI study[J]. Pain Ther, 2022, 11(2): 561-574. DOI: 10.1007/s40122-022-00365-1.
[12]
Wang LP, Zhang XZ, Guo J, et al. Efficacy of acupuncture for migraine prophylaxis: a single-blinded, double-dummy, randomized controlled trial[J]. Pain, 2011, 152(8): 1864-1871. DOI: 10.1016/j.pain.2011.04.006.
[13]
Liu HY, Lee PL, Chou KH, et al. The cerebellum is associated with 2-year prognosis in patients with high-frequency migraine[J]. J Headache Pain, 2020, 21(1): 29. DOI: 10.1186/s10194-020-01096-4.
[14]
Zhu YD, Dai LL, Zhao HR, et al. Alterations in effective connectivity of the Hippocampus in migraine without aura[J]. J Pain Res, 2021, 14: 3333-3343. DOI: 10.2147/JPR.S327945.
[15]
Mehnert J, May A. Functional and structural alterations in the migraine cerebellum[J]. J Cereb Blood Flow Metab, 2019, 39(4): 730-739. DOI: 10.1177/0271678X17722109.
[16]
Bonanno L, Lo Buono V, de Salvo S, et al. Brain morphologic abnormalities in migraine patients: an observational study[J]. J Headache Pain, 2020, 21(1): 39. DOI: 10.1186/s10194-020-01109-2.
[17]
Wang JH, Liu B, Yu DH, et al. Voxel-based gray matter volume study in patients with vestibular migraine[J]. Chin J Magn Reson Imaging, 2021, 12(3): 67-70, 88. DOI: 10.12015/issn.1674-8034.2021.03.015.
[18]
Wiech K, Ploner M, Tracey I. Neurocognitive aspects of pain perception[J]. Trends Cogn Sci, 2008, 12(8): 306-313. DOI: 10.1016/j.tics.2008.05.005.
[19]
Huang XB, Zhang D, Chen YC, et al. Altered functional connectivity of the red nucleus and substantia nigra in migraine without aura[J]. J Headache Pain, 2019, 20(1): 104. DOI: 10.1186/s10194-019-1058-0.
[20]
Qin ZX, Su JJ, He XW, et al. Disrupted functional connectivity between sub-regions in the sensorimotor areas and cortex in migraine without aura[J]. J Headache Pain, 2020, 21(1): 47. DOI: 10.1186/s10194-020-01118-1.
[21]
Kim JH, Kim JB, Suh SI, et al. Thickening of the somatosensory cortex in migraine without aura[J]. Cephalalgia, 2014, 34(14): 1125-1133. DOI: 10.1177/0333102414531155.
[22]
Ninomiya T, Sawamura H, Inoue K, et al. Segregated pathways carrying frontally derived top-down signals to visual areas MT and V4 in macaques[J]. J Neurosci, 2012, 32(20): 6851-6858. DOI: 10.1523/JNEUROSCI.6295-11.2012.
[23]
Wei HL, Zhou X, Chen YC, et al. Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura[J]. J Headache Pain, 2019, 20(1): 116. DOI: 10.1186/s10194-019-1065-1.
[24]
Wei HL, Yu YS, Chen JN, et al. Changed functional connectivity of the visual network in patients with migraineurs without aura[J]. Chin J Behav Med Brain Sci, 2021, 30(2): 139-144. DOI: 10.3760/cma.j.cn371468-20201015-01796.
[25]
Ma PH, Dong XH, Qu YZ, et al. A narrative review of neuroimaging studies in acupuncture for migraine[J]. Pain Res Manag, 2021, 2021: 9460695. DOI: 10.1155/2021/9460695.
[26]
Liu SS, Luo SL, Yan TW, et al. Differential modulating effect of acupuncture in patients with migraine without aura: a resting functional magnetic resonance study[J]. Front Neurol, 2021, 12: 680896. DOI: 10.3389/fneur.2021.680896.
[27]
Zhao L, Liu JX, Zhang FW, et al. Effects of long-term acupuncture treatment on resting-state brain activity in migraine patients: a randomized controlled trial on active acupoints and inactive acupoints[J]. PLoS One, 2014, 9(6): e99538. DOI: 10.1371/journal.pone.0099538.
[28]
Wei XY, Luo SL, Chen H, et al. Functional connectivity changes during migraine treatment with electroacupuncture at Shuaigu (GB8)[J]. J Integr Med, 2022, 20(3): 237-243. DOI: 10.1016/j.joim.2022.01.009.
[29]
Yang XJ, Liu L, Xu ZL, et al. Baseline brain gray matter volume as a predictor of acupuncture outcome in treating migraine[J]. Front Neurol, 2020, 11: 111. DOI: 10.3389/fneur.2020.00111.
[30]
Zhang YT, Wang ZW, du JR, et al. Regulatory effects of acupuncture on emotional disorders in patients with menstrual migraine without aura: a resting-state fMRI study[J]. Front Neurosci, 2021, 15: 726505. DOI: 10.3389/fnins.2021.726505.

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