Share this content in WeChat
Original Article
Dynamic changes of regional homogeneity in patients with Parkinson's disease based on resting-state functional magnetic resonance imaging
LU Yao  LI Yan  YANG Wenrui  YANG Li  ZHANG Hongying  XU Yao  WU Jingtao 

Cite this article as: Lu Y, Li Y, Yang WR, et al. Dynamic changes of regional homogeneity in patients with Parkinson's disease based on resting-state functional magnetic resonance imaging[J]. Chin J Magn Reson Imaging, 2022, 13(6): 45-49. DOI:10.12015/issn.1674-8034.2022.06.009.

[Abstract] Objective To examine abnormal dynamic characteristics of regional homogeneity in Parkinson's disease (PD) patients by resting-state functional magenetic resonance imaging (rs-fMRI) and to investigate whether the altered dynamic regional characteristics were associated with the clinical behavior scores in PD patients.Materials and Methods The rs-fMRI data of 32 PD patients (PD group) who have enrolled in the Subei People's Hospital from August 2018 to August 2021 and 33 age-and sex-matched healthy controls (HC group) were prospectively collected. Temporal dynamic analysis (TDA) toolbox based on MATLAB were used for data processing. The differences of dynamic regional homogeneity (dReHo) between PD and HC groups were detected by two sample t-test. The cognitive function of the patients was evaluated with the Mini-Mental State Examination (MMSE) scores and Montreal Cognitive Assessment scores. The third part of Unified Parkinson's disease Rating Scale (UPDRS) was used to assess the patients' motor function. Pearson correlation was used to analyze the correlation between dReHo in regions showing significant intergroup differences and clinical scores. Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic value of altered dReHo indexes to identify PD patients.Results Compared with HC group, PD group showed decreased dReHo in left caudate,right putamen and bilateral lingual (P<0.05). The dReHo variability in left caudate (r=0.374, P=0.04) and right putamen (r=0.379, P=0.03) was positively correlated with the MMSE scores of the PD patients. The dReHo variability in the left caudate (r=-0.446, P=0.01), right putamen (r=-0.369, P=0.04) and left lingual (r=-0.419, P=0.02) was negatively correlated with the UPDRS-Ⅲ scores of the PD patients. Furthermore, ROC curve analysis demonstrated a higher diagnostic performance of altered dynamic regional characteristics to identify PD patients.Conclusions PD patients have abnormal brain activity at resting state, which affects the movement and cognitive function. The dynamic regional homogeneity variability in related brain regions could distinguish Parkinson's patients from healthy controls at the individual level.
[Keywords] Parkinson's disease;resting-state functional magnetic resonance imaging;regional homogeneity;dynamic characteristic;logistic regression

LU Yao1, 2   LI Yan2, 3   YANG Wenrui2, 3   YANG Li2, 3   ZHANG Hongying2   XU Yao2   WU Jingtao2*  

1 Yangzhou University, Yangzhou 225009, China

2 Department of Imaging, Subei People's Hospital, Yangzhou 225001, China

3 Dalian Medical University, Dalian 116044, China

Wu JT, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81571652).
Received  2022-01-17
Accepted  2022-05-05
DOI: 10.12015/issn.1674-8034.2022.06.009
Cite this article as: Lu Y, Li Y, Yang WR, et al. Dynamic changes of regional homogeneity in patients with Parkinson's disease based on resting-state functional magnetic resonance imaging[J]. Chin J Magn Reson Imaging, 2022, 13(6): 45-49. DOI:10.12015/issn.1674-8034.2022.06.009.

Armstrong MJ, Okun MS. Diagnosis and treatment of parkinson disease: a review[J]. JAMA, 2020, 323(6): 548-560. DOI: 10.1001/jama.2019.22360.
Luo B, Lu Y, Qiu C, et al. Altered spontaneous neural activity and functional connectivity in Parkinson's disease with subthalamic microlesion[J]. Front Neurosci, 2021, 15: 699010. DOI: 10.3389/fnins.2021.699010.
Zang YF, Jiang TZ, Lu YL, et al. Regional homogeneity approach to fMRI data analysis[J]. NeuroImage, 2004, 22(1): 394-400. DOI: 10.1016/j.neuroimage.2003.12.030.
Wang SW, Zhang YL, Lei JQ, et al. Investigation of sensorimotor dysfunction in Parkinson disease by resting-state fMRI[J]. Neurosci Lett, 2021, 742: 135512. DOI: 10.1016/j.neulet.2020.135512.
Wang SW, Zhang YL, Gou LB, et al. Regional Brain Function Changes and Functional Connectivity in Parkinson's Disease Patients with Sensorimotor Dysfunction[J]. J Clin Radiol, 2021, 40(6): 1060-1064. DOI: 10.13437/j.cnki.jcr.2021.06.006.
Hensel L, Hoffstaedter F, Caspers J, et al. Functional connectivity changes of key regions for motor initiation in Parkinson's disease[J]. Cereb Cortex, 2019, 29(1): 383-396. DOI: 10.1093/cercor/bhy259.
Jeong SH, Lee HS, Jung JH, et al. Associations between white matter hyperintensities, striatal dopamine loss, and cognition in drug-naïve Parkinson's disease[J]. Parkinsonism Relat Disord, 2022, 97: 1-7. DOI: 10.1016/j.parkreldis.2022.02.020.
Galtier I, Nieto A, Mata M, et al. Analyses of visuospatial and visuoperceptual errors as predictors of dementia in Parkinson's disease patients with subjective cognitive decline and mild cognitive impairment[J]. J Int Neuropsychol Soc, 2021, 27(7): 722-732. DOI: 10.1017/S1355617720001216.
Specketer K, Zabetian CP, Edwards KL, et al. Visuospatial functioning is associated with sleep disturbance and hallucinations in nondemented patients with Parkinson's disease[J]. J Clin Exp Neuropsychol, 2019, 41(8): 803-813. DOI: 10.1080/13803395.2019.1623180.
Chen J, Sun DL, Shi YH, et al. Dynamic alterations in spontaneous neural activity in multiple brain networks in subacute stroke patients: a resting-state fMRI study[J]. Front Neurosci, 2018, 12: 994. DOI: 10.3389/fnins.2018.00994.
Zhang C, Dou BR, Wang JL, et al. Dynamic alterations of spontaneous neural activity in Parkinson's disease: a resting-state fMRI study[J]. Front Neurol, 2019, 10: 1052. DOI: 10.3389/fneur.2019.01052.
Yan JH, Li M, Fu SS, et al. Alterations of dynamic regional homogeneity in trigeminal neuralgia: a resting-state fMRI study[J]. Front Neurol, 2019, 10: 1083. DOI: 10.3389/fneur.2019.01083.
Jiang L, Ma XJ, Liu H, et al. Aberrant dynamics of regional coherence measured by resting-state fMRI in children with benign epilepsy with centrotemporal spikes (BECTS)[J]. Front Neurol, 2021, 12: 712071. DOI: 10.3389/fneur.2021.712071.
Chen LH, Sun JW, Wang QH, et al. Altered temporal dynamics of brain activity in multiple-frequency bands in non-neuropsychiatric systemic lupus erythematosus patients with inactive disease[J]. Neuropsychiatr Dis Treat, 2021, 17: 1385-1395. DOI: 10.2147/NDT.S292302.
Lu FM, Zhao Y, He ZL, et al. Altered dynamic regional homogeneity in patients with conduct disorder[J]. Neuropsychologia, 2021, 157: 107865. DOI: 10.1016/j.neuropsychologia.2021.107865.
Sun FP, Liu ZN, Yang J, et al. Differential dynamical pattern of regional homogeneity in bipolar and unipolar depression: a preliminary resting-state fMRI study[J]. Front Psychiatry, 2021, 12: 764932. DOI: 10.3389/fpsyt.2021.764932.
Postuma RB, Berg D, Stern M, et al. MDS clinical diagnostic criteria for Parkinson's disease[J]. Mov Disord, 2015, 30(12): 1591-1601. DOI: 10.1002/mds.26424.
Lee WW, Yoon EJ, Lee JY, et al. Visual hallucination and pattern of brain degeneration in Parkinson's disease[J]. Neurodegener Dis, 2017, 17(2/3): 63-72. DOI: 10.1159/000448517.
Kurita A, Koshikawa H, Akiba T, et al. Visual hallucinations and impaired conscious visual perception in parkinson disease[J]. J Geriatr Psychiatry Neurol, 2020, 33(6): 377-385. DOI: 10.1177/0891988719892318.
Hu XF, Zhang JQ, Jiang XM, et al. Amplitude of low-frequency oscillations in Parkinson's disease: a 2-year longitudinal resting-state functional magnetic resonance imaging study[J]. Chin Med J (Engl), 2015, 128(5): 593-601. DOI: 10.4103/0366-6999.151652.
Gallea C, Wicki B, Ewenczyk C, et al. Antisaccade, a predictive marker for freezing of gait in Parkinson's disease and gait/gaze network connectivity[J]. Brain, 2021, 144(2): 504-514. DOI: 10.1093/brain/awaa407.
Bharti K, Suppa A, Pietracupa S, et al. Aberrant functional connectivity in patients with Parkinson's disease and freezing of gait: a within- and between-network analysis[J]. Brain Imaging Behav, 2020, 14(5): 1543-1554. DOI: 10.1007/s11682-019-00085-9.
Roalf DR, Sydnor VJ, Woods M, et al. A quantitative meta-analysis of brain glutamate metabolites in aging[J]. Neurobiol Aging, 2020, 95: 240-249. DOI: 10.1016/j.neurobiolaging.2020.07.015.
Alarcón F, Maldonado JC, Cañizares M, et al. Motor dysfunction as a prodrome of Parkinson's disease[J]. J Parkinsons Dis, 2020, 10(3): 1067-1073. DOI: 10.3233/JPD-191851.
Martin WRW, Wieler M, Gee M. Midbrain iron content in early Parkinson disease: a potential biomarker of disease status[J]. Neurology, 2008, 70(16Pt 2): 1411-1417. DOI: 10.1212/01.wnl.0000286384.31050.b5.
Foo H, Mak E, Yong TT, et al. Progression of subcortical atrophy in mild Parkinson's disease and its impact on cognition[J]. Eur J Neurol, 2017, 24(2): 341-348. DOI: 10.1111/ene.13205.
Lee JE, Cho KH, Song SK, et al. Exploratory analysis of neuropsychological and neuroanatomical correlates of progressive mild cognitive impairment in Parkinson's disease[J]. J Neurol Neurosurg Psychiatry, 2014, 85(1): 7-16. DOI: 10.1136/jnnp-2013-305062.
Zhang Y, Wang X, Li Y. Disrupted dynamic pattern of regional neural activity in early-stage cognitively normal Parkinson's disease[J]. Acta Radiol, 2021: 2021Nov15;2841851211055401. DOI: 10.1177/02841851211055401.

PREV Investigate the whole level alteration of dynamic functional connectivity of attention network in patients with major depressive disorder based on magnetic resonance imaging
NEXT Changes in voxel-mirrored homotopic connectivity of bilateral cuneus after acupuncture in migraine without aura patients

Tel & Fax: +8610-67113815    E-mail: