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Original Article
Dynamic changes of regional homogeneity in patients with Parkinson's disease based on resting-state functional magnetic resonance imaging
LU Yao  LI Yan  YANG Wenrui  YANG Li  ZHANG Hongying  XU Yao  WU Jingtao 

Cite this article as: Lu Y, Li Y, Yang WR, et al. Dynamic changes of regional homogeneity in patients with Parkinson's disease based on resting-state functional magnetic resonance imaging[J]. Chin J Magn Reson Imaging, 2022, 13(6): 45-49. DOI:10.12015/issn.1674-8034.2022.06.009.


[Abstract] Objective To examine abnormal dynamic characteristics of regional homogeneity in Parkinson's disease (PD) patients by resting-state functional magenetic resonance imaging (rs-fMRI) and to investigate whether the altered dynamic regional characteristics were associated with the clinical behavior scores in PD patients.Materials and Methods The rs-fMRI data of 32 PD patients (PD group) who have enrolled in the Subei People's Hospital from August 2018 to August 2021 and 33 age-and sex-matched healthy controls (HC group) were prospectively collected. Temporal dynamic analysis (TDA) toolbox based on MATLAB were used for data processing. The differences of dynamic regional homogeneity (dReHo) between PD and HC groups were detected by two sample t-test. The cognitive function of the patients was evaluated with the Mini-Mental State Examination (MMSE) scores and Montreal Cognitive Assessment scores. The third part of Unified Parkinson's disease Rating Scale (UPDRS) was used to assess the patients' motor function. Pearson correlation was used to analyze the correlation between dReHo in regions showing significant intergroup differences and clinical scores. Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic value of altered dReHo indexes to identify PD patients.Results Compared with HC group, PD group showed decreased dReHo in left caudate,right putamen and bilateral lingual (P<0.05). The dReHo variability in left caudate (r=0.374, P=0.04) and right putamen (r=0.379, P=0.03) was positively correlated with the MMSE scores of the PD patients. The dReHo variability in the left caudate (r=-0.446, P=0.01), right putamen (r=-0.369, P=0.04) and left lingual (r=-0.419, P=0.02) was negatively correlated with the UPDRS-Ⅲ scores of the PD patients. Furthermore, ROC curve analysis demonstrated a higher diagnostic performance of altered dynamic regional characteristics to identify PD patients.Conclusions PD patients have abnormal brain activity at resting state, which affects the movement and cognitive function. The dynamic regional homogeneity variability in related brain regions could distinguish Parkinson's patients from healthy controls at the individual level.
[Keywords] Parkinson's disease;resting-state functional magnetic resonance imaging;regional homogeneity;dynamic characteristic;logistic regression

LU Yao1, 2   LI Yan2, 3   YANG Wenrui2, 3   YANG Li2, 3   ZHANG Hongying2   XU Yao2   WU Jingtao2*  

1 Yangzhou University, Yangzhou 225009, China

2 Department of Imaging, Subei People's Hospital, Yangzhou 225001, China

3 Dalian Medical University, Dalian 116044, China

Wu JT, E-mail: wujingtaodoctor@126.com

Conflicts of interest   None.

Received  2022-01-17
Accepted  2022-05-05
DOI: 10.12015/issn.1674-8034.2022.06.009
Cite this article as: Lu Y, Li Y, Yang WR, et al. Dynamic changes of regional homogeneity in patients with Parkinson's disease based on resting-state functional magnetic resonance imaging[J]. Chin J Magn Reson Imaging, 2022, 13(6): 45-49.DOI:10.12015/issn.1674-8034.2022.06.009

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