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Original Article
A clinical study of amygdala volume changes in medial temporal lobe epilepsy patients
GU Xin  XU Fei  ZHANG Liling  WANG Yunling  DING Shuang 

Cite this article as: Gu X, Xu F, Zhang LL, et al. A clinical study of amygdala volume changes in medial temporal lobe epilepsy patients[J]. Chin J Magn Reson Imaging, 2022, 13(6): 36-39. DOI:10.12015/issn.1674-8034.2022.06.007.


[Abstract] Objective The changes of hippocampus and amygdala volume in patients with medial temporal lobe epilepsy were studied by using T1 three dimensional magnetization prepared rapid acquisition gradient echo (3D-T1 MPRAGE) sequence and FreeSufer software to measure the volume of hippocampus and amygdala.Materials and Methods A total of 102 patients with medial temporal lobe epilepsy (case group) and 15 healthy volunteers (control group) were collected to measure the volume of bilateral hippocampus and amygdala respectively, and the abnormality was judged by taking the mean value of the control group plus or minus 2 times the standard deviation as the normal limit. According to whether the hippocampal volume is normal or not, the patients with amygdala enlargement (AE) in the hippocampal sclerosis (HS) group and the normal hippocampal group were divided into L group and R group according to the epilepsy side. Paired t-test was used to compare bilateral amygdala volumes. One-way ANOVA was used to compare the ipsilateral amygdala of the normal hippocampus-L group, the normal hippocampal-R group and the normal control group; the ipsilateral amygdala of the HS-L group, the HS-R group and the normal control group was compared.Results The study found that there was a statistically significant difference in the volume of bilateral amygdala between normal hippocampal-L group and normal hippocampal-R group (P<0.05). There was a statistically significant difference in the volume of bilateral amygdala between HS-L group and HS-R group (P<0.05). The volume of the right amygdala in the HS-L group was larger than that of the HS-R group and the same side of the control group (P<0.05). The volume of the left amygdala in the HS-R group was greater than that in the HS-L group and the same side of the control group (P<0.05). The volume of the left amygdala in the normal hippocampus-L group was larger than that in the normal hippocampus-R group and the ipsilateral side of the control group (P<0.05). The volume of the right amygdala in the normal hippocampus-R group was larger than that in the normal hippocampus-L group and control group on the same side (P<0.05).Conclusions 3D-T1 MPRAGE can accurately measure the volume of the amygdala. Meanwhile, patients with normal hippocampus in mesial temporal lobe epilepsy have amygdala enlargement on the same side of the epileptogenic foci, and HS patients have amygdala enlargement on the opposite side of the epileptic foci, indicating that the amygdala may be involved in the occurrence and development of mesial temporal lobe epilepsy.
[Keywords] medial temporal lobe epilepsy;hippocampus;amygdala volume;magnetic resonance imaging;T1 three dimensional magnetization prepared rapid acquisition gradient echo sequence

GU Xin   XU Fei   ZHANG Liling   WANG Yunling   DING Shuang*  

Department of MRI, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China

Ding S, E-mail: dingshuangxxx@163.com

Conflicts of interest   None.

Received  2021-11-17
Accepted  2022-05-31
DOI: 10.12015/issn.1674-8034.2022.06.007
Cite this article as: Gu X, Xu F, Zhang LL, et al. A clinical study of amygdala volume changes in medial temporal lobe epilepsy patients[J]. Chin J Magn Reson Imaging, 2022, 13(6): 36-39.DOI:10.12015/issn.1674-8034.2022.06.007

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