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Clinical Article
Comparison of echo-planar and turbo spin-echo diffusion-weighted imaging sequence in the diagnosis of middle ear cholesteatoma
FAN Xiaoxue  DING Changwei  LIU Zhaoyu 

Cite this article as: Fan XX, Ding CW, Liu ZY. Comparison of echo-planar and turbo spin-echo diffusion-weighted imaging sequence in the diagnosis of middle ear cholesteatoma[J]. Chin J Magn Reson Imaging, 2022, 13(6): 5-9. DOI:10.12015/issn.1674-8034.2022.06.002.

[Abstract] Objective To compare the diagnostic performance of echo planar diffusion weighted imaging (EP-DWI) and turbo spin-echo diffusion weighted imaging (TSE-DWI) for middle ear cholesteatoma.Materials and Methods This study prospectively enrolled 63 patients with preliminary clinical suspicion of middle ear cholesteatoma; all patients underwent EP-DWI and TSE-DWI scans using a Philips Ingenia 3.0 T superconducting magnetic resonance scanner and a 32-channel head coil and subsequent surgical treatment. Using pathological results as the gold standard, the imaging diagnosis and postoperative pathology were compared, and area under the curve (AUC), sensitivity, specificity, positive predictive value, and negative predictive value of EP-DWI and TSE-DWI sequences in the diagnosis of suspected cholesteatoma were calculated.Results Among the 63 patients with suspected middle ear cholesteatoma, 47 were pathologically diagnosed as cholesteatoma and 16 were non-cholesteatoma. The accuracy of TSW-DWI in the diagnosis of middle ear cholesteatoma was significantly higher than that of EP-DWI (TSE-DWI vs. EP-DWI: 0.895 vs. 0.644, P<0.05). The sensitivity (91.49%) and specificity (87.50%) of TSE-DWI in diagnosing cholesteatoma were higher than those of the EP-DWI (sensitivity: 78.72%, specificity: 50.00%) sequence.Conclusions Compared with EP-DWI, TSE-DWI can significantly improve diagnostic accuracy and reduce the misdiagnosis rate. TSE-DWI can improve the diagnostic confidence in middle ear cholesteatoma and has a high application value for clinical diagnosis.
[Keywords] middle ear;cholesteatoma;diffusion-weighted imaging;echo planar;turbo spin-echo;magnetic resonance imaging;diagnosis

FAN Xiaoxue   DING Changwei   LIU Zhaoyu*  

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110000, China

Liu ZY, E-mail:

Conflicts of interest   None.

Received  2022-03-28
Accepted  2022-05-27
DOI: 10.12015/issn.1674-8034.2022.06.002
Cite this article as: Fan XX, Ding CW, Liu ZY. Comparison of echo-planar and turbo spin-echo diffusion-weighted imaging sequence in the diagnosis of middle ear cholesteatoma[J]. Chin J Magn Reson Imaging, 2022, 13(6): 5-9.DOI:10.12015/issn.1674-8034.2022.06.002

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