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Original Article
Experimental study of IVIM evaluating acute mesenteric ischemia induced by mesenteric artery embolization in rabbits
BA Chenghui  WANG Xinyu  XU Chang  CHEN Liang  ZHONG Xiaofei  CAO Zhang  ZHANG Diming  ZHANG Juntao  JIANG Xingyue 

Cite this article as: Ba CH, Wang XY, Xu C, et al. Experimental study of IVIM evaluating acute mesenteric ischemia induced by mesenteric artery embolization in rabbits[J]. Chin J Magn Reson Imaging, 2022, 13(5): 82-88. DOI:10.12015/issn.1674-8034.2022.05.015.

[Abstract] Objective To quantitatively evaluate the early signs and dynamic evolution of acute mesenteric ischemia (AMI) by 3.0 T magnetic resonance intravoxel incoherent motion (IVIM) diffusion weighted imaging.Materials and Methods Sixty-six New Zealand rabbits were selected as research subjects and randomly divided into experimental group and control group, including 11 time nodes (1 h, 1.5 h, 2 h, 2.5 h, 3 h, 3.5 h, 4 h, 4.5 h, 5 h, 5.5 h, 6 h), 33 rabbits in each group, 3 rabbits in each time node. Acute intestinal ischemia model was established in the experimental group before ligation of the main mesenteric artery, while in the control group, only ligation was performed. IVIM examination was performed on 3.0 T MR, and pathological specimens were collected and made after the scanning. The IVIM parameters were obtained by post-processing the image. One-way ANOVA was used to compare the differences of parameters between the experimental group and the control group. The imaging results were compared with pathological results to analyze the quantitative evaluation value of IVIM in acute intestinal ischemia.Results Using pathological results as the gold standard, when mesenteric ischemia occurred for about 2 hours, the f and D values of the experimental group were lower than those of the sham operation group (D value<1.0×10-3 mm2/s, f value<0.3), the difference was statistically significant (P<0.05), but there was no significant difference between the experimental group and the sham operation group (P>0.05). Pathological results showed that only intestinal wall mucosa was affected by ischemia at this time. When mesenteric ischemia reached 4 h, f value, D value and D* value were significantly different between the experimental group and the sham operation group (P<0.05). When mesenteric ischemia reached about 4.5 h, the f value and D value further decreased (D value<1.0×10-3 mm2/s, 0<f value<0.1), and the D* value decreased, with statistical significance (P<0.05). At this time, the pathological results showed muscle layer involvement. When mesenteric ischemia time reached 5.5 h, f value was close to 0, D value increased significantly (D value>1.0×10-3 mm2/s), and D* value was roughly the same as before. There was no statistical significance in D value and D* value between the experimental group and the sham operation group (P>0.05). At this time, intestinal wall ischemia had already affected the muscle layer or even the whole intestinal wall.Conclusions The f value and D value of IVIM quantitative parameters are helpful for the early dynamic monitoring and quantitative evaluation of AMI in rabbits, and provide theoretical experimental basis for clinical application.
[Keywords] acute mesenteric ischemia;magnetic resonance imaging;intravoxel incoherent motion;New Zealand rabbits;early diagnosis

BA Chenghui1   WANG Xinyu1   XU Chang1   CHEN Liang1   ZHONG Xiaofei1   CAO Zhang2   ZHANG Diming1   ZHANG Juntao3   JIANG Xingyue1*  

1 Department of Radiology, Affiliated Hospital of Binzhou Medical University, Binzhou 256600, China

2 Department of Pathology, Affiliated Hospital of Binzhou Medical University, Binzhou 256600, China

3 GE Healthcare Shanghai Co.,Ltd., Precision Health Institution, Shanghai 210000, China

Jiang XY, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS Natural Science Foundation of Shandong Province (No. ZR2018LH015).
Received  2021-12-15
Accepted  2022-04-07
DOI: 10.12015/issn.1674-8034.2022.05.015
Cite this article as: Ba CH, Wang XY, Xu C, et al. Experimental study of IVIM evaluating acute mesenteric ischemia induced by mesenteric artery embolization in rabbits[J]. Chin J Magn Reson Imaging, 2022, 13(5): 82-88. DOI:10.12015/issn.1674-8034.2022.05.015.

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