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Original Article
Functional connectivity of the cerebellar Crus Ⅰ in type 2 diabetes mellitus:A resting-state functional MRI study
TIAN Jing  ZHAO Lianping  LIU Ruifang  LU Yashan  HUANG Gang  GONG Rui  LIANG Fengli  GAO Yanyan  ZHANG Wenwen 

Cite this article as: Tian J, Zhao LP, Liu RF, et al. Functional connectivity of the cerebellar Crus Ⅰ in type 2 diabetes mellitus: A resting-state functional MRI study[J]. Chin J Magn Reson Imaging, 2022, 13(5): 64-69. DOI:10.12015/issn.1674-8034.2022.05.012.

[Abstract] Objective To investigate the alteration of functional connectivity (FC) between cerebellar Crus Ⅰ and the whole-brain in patients with type 2 diabetes mellitus (T2DM) using resting-state functional MRI (rs-fMRI).Materials and Methods Seventy-eight T2DM patients and fifty-seven healthy subjects (HCs) matched in gender, age and years of education were prospectively collected pertaining to clinical data, neuropsychological test and rs-fMRI data. Seed-based FC analysis was calculated using bilateral cerebellar Crus Ⅰa and Crus Ⅰb as seed points. The differences of cerebellar FC values, clinical variables, differences in test scores and correlations between the two groups were statistically analyzed.Results Compared with the HCs, T2DM had presented higher scores of Beck Depression Self-assessment Questionnaire, Beck Anxiety Scale, and lower scores of Montreal Cognitive Assessment (P<0.05); the FC between the left cerebellar Crus Ⅰa and left lingual gyrus/cerebellum Ⅳ-Ⅴ was decreased, and the FC between the right cerebellar Crus Ⅰb and right inferior frontal gyrus was increased (GRF correction, voxel-P<0.005, cluster-P<0.05), and the latter was positively correlated with low density lipoprotein (r=0.30, P=0.01).Conclusions The abnormal FC values of cerebellar subregions may be involved in the neuropathology of T2DM cognitive and mood dysfunction.
[Keywords] diabetes mellitus, type 2;resting-state functional magnetic resonance imaging;cerebellum;brain damage, chronic;cognitive dysfunction;mood disorders;functional connectivity

TIAN Jing1   ZHAO Lianping1, 2*   LIU Ruifang1   LU Yashan2   HUANG Gang1, 2   GONG Rui3   LIANG Fengli2   GAO Yanyan2   ZHANG Wenwen2  

1 First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Lanzhou 730000, China

2 Department of Radiology, Gansu Provincial Hospital, Lanzhou 730000, China

3 Cadre Endocrinology Department, Gansu Provincial Hospital, Lanzhou 730000, China

Zhao LP, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81901724, 81860306); Natural Science Foundation of Gansu Province (No. 20JR5RA156, 21JR7RA593); "Young Scholars in Western China" Project of the Chinese Academy of Sciences in 2020; the Foundation of Gansu Provincial Hospital (No. 19SYPYA-2); Outstanding Graduate Student Innovation Star Program in 2021 (No. 2021CXZX-738).
Received  2021-10-23
Accepted  2022-04-13
DOI: 10.12015/issn.1674-8034.2022.05.012
Cite this article as: Tian J, Zhao LP, Liu RF, et al. Functional connectivity of the cerebellar Crus Ⅰ in type 2 diabetes mellitus: A resting-state functional MRI study[J]. Chin J Magn Reson Imaging, 2022, 13(5): 64-69. DOI:10.12015/issn.1674-8034.2022.05.012.

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