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Clinical Article
Deep gray matter changes in relapsing-remitting multiple sclerosis detected by multimodal MRI
WANG Xiaohua  DING Shuang  CHEN Xiaoya  ZENG Chun  YIN Feiyue  LI Yongmei 

Cite this article as: Wang XH, Ding S, Chen XY, et al. Deep gray matter changes in relapsing-remitting multiple sclerosis detected by multimodal MRI[J]. Chin J Magn Reson Imaging, 2022, 13(5): 23-27. DOI:10.12015/issn.1674-8034.2022.05.005.


[Abstract] Objective To quantify the deep gray matter changes at the relatively early course of relapsing-remitting multiple sclerosis (RRMS) patients by multimodal MRI, and explore its correlation with white matter lesion and clinical disability.Materials and Methods 3D-T1 weighted imaging, 3D-fluid attenuated inversion recovery, quantitative sensitivity mapping and diffusion tensor imaging scans were performed on 40 patients with RRMS and 32 healthy controls (HC) to obtain gray matter nucleus volume, quantitative susceptibility value (QSV), fractional anisotropy (FA) and mean diffusivity (MD) values and white matter lesion volume (WM-LV). The independent sample t-test was used to compare the differences in the gray matter nucleus volume, QSV, FA and MD values between groups, and correlation analysis was used to assess the relationship between the indicators and the Extended Disability Scale (EDSS) score and WM-LV.Results Compared with the control group, the volume of each nucleus in the RRMS group was reduced (all P<0.05), and the QSV of the thalamus was reduced (P<0.05); the FA value of the caudate nucleus and thalamus were reduced, and the MD value were increased (P<0.05). Correlation analysis showed the volume of each nucleus and the FA value of the caudate nucleus were negatively correlated with WM-LV (r=-0.315, r=-0.531, r=-0.563, r=-0.635, r=-0.543, all P<0.05), and the MD values of the caudate nucleus, putamen and thalamus were positively correlated with WM-LV (r=0.620, r=0.671, r=0.558, all P<0.01), the FA and MD values of the remaining nuclei and the QSV of each nucleus were not significantly correlated with WM-LV (all P>0.05); the EDSS score was significantly negatively correlated with QSV of the thalamus (rs=-0.370, P=0.019).Conclusions In relatively early RRMS, the deep gray matter is significantly atrophy, accompanied by microstructure damage and iron disorders, which partly independent of the focal demyelination of white matter; the involvement of the thalamus is an essential feature of RRMS and its iron concentration may be a marker of disease severity in MS to monitor disease progression.
[Keywords] relapsing-remitting multiple sclerosis;deep gray matter;multimodal magnetic resonance imaging;quantitative susceptibility mapping;diffusion tensor imaging

WANG Xiaohua   DING Shuang   CHEN Xiaoya   ZENG Chun   YIN Feiyue   LI Yongmei*  

Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

Li YM, E-mail: lymzhang70@aliyun.com

Conflicts of interest   None.

Received  2021-12-15
Accepted  2022-04-01
DOI: 10.12015/issn.1674-8034.2022.05.005
Cite this article as: Wang XH, Ding S, Chen XY, et al. Deep gray matter changes in relapsing-remitting multiple sclerosis detected by multimodal MRI[J]. Chin J Magn Reson Imaging, 2022, 13(5): 23-27.DOI:10.12015/issn.1674-8034.2022.05.005

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