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Diffusion kurtosis imaging study on changes of brain microstructure and cognitive function in breast cancer survivors with chemotherapy
HAN Yong  YANG Qilin  ZHAO Yuanjing  PAN Changjie 

Cite this article as: Han Y, Yang QL, Zhao YJ, et al. Diffusion kurtosis imaging study on changes of brain microstructure and cognitive function in breast cancer survivors with chemotherapy[J]. Chin J Magn Reson Imaging, 2022, 13(4): 111-114. DOI:10.12015/issn.1674-8034.2022.04.021.


[Abstract] Objective To study changes of brain microstructure and cognitive function after chemotherapy in breast cancer survivors by using voxel-based analysis of diffusion kurtosis imaging (DKI).Materials and Methods A total of 23 breast cancer patients (Stage Ⅰ-Ⅲ), confirmed by pathology, and 26 age-and gender-matched control healthy volunteers were recruited for prospective Neuropsychological assessments and DKI data acquisition. The statistical product and SPSS 25.0 software was performed to evaluate the difference of subjects' general clinical data and mean kurtosis (MK), axial kurtosis (AK), radial kurtosis (RK) value, the correlation between DKI parameters of different brain regions and neuropsychological assessments scores were analyzed.Results There were no statistically significant differences in neuropsychological scores and MK, AK, RK value between the chemotherapy group and the control group before chemotherapy. There were statistically significant differences in Montreal Cognitive Assessment Scale (MoCA), Clock Drawing Test, Auditory Verbal Learning Delay 5 min Test (AVLT2) scores and MK, RK value before and after chemotherapy (P<0.05). MK value in the genu of corpus callosum, the right posterior cingulate gyrus and the right superior frontal gyrus decreased significantly; RK value in the posterior cingulate gyrus, the right middle frontal gyrus decreased significantly after chemotherapy by false discovery rate (P<0.05). Correlation analysis shows that MK value of the right posterior cingulate gyrus was positively correlated with AVLT2 results (r=0.548, P=0.007); RK value of the posterior cingulate gyrus was positively correlated with MoCA results (r=0.654, P=0.001) after chemotherapy.Conclusions In the short term, there are dominant region associated with cognitive impairment in breast cancer survivors with chemotherapy. The MK, RK value can be sensitive to changes of brain microstructure, and provide valuable reference for early evaluation of chemotherapy-related cognitive impairment.
[Keywords] breast cancer;diffusion kurtosis imaging;brain damage;chemotherapy-related cognitive impairment

HAN Yong1   YANG Qilin2   ZHAO Yuanjing2   PAN Changjie2*  

1 Department of Radiology, Shanghai Fifth People's Hospital of Fudan University, Shanghai 201100, China

2 Department of Radiology, Changzhou No. 2 People's Hospital, Changzhou 213100, China

Pan CJ, E-mail: pcj424815@sina.com

Conflicts of interest   None.

Received  2021-09-17
Accepted  2022-03-25
DOI: 10.12015/issn.1674-8034.2022.04.021
Cite this article as: Han Y, Yang QL, Zhao YJ, et al. Diffusion kurtosis imaging study on changes of brain microstructure and cognitive function in breast cancer survivors with chemotherapy[J]. Chin J Magn Reson Imaging, 2022, 13(4): 111-114.DOI:10.12015/issn.1674-8034.2022.04.021

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