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Original Article
Compared study on the efficacy and safety of MR and CT guided percutaneous VX2 hepatic para-vascular tumor model in rabbits
FENG Xu  FENG Guiling  LIU Yan  SUN Baijintao  LI Bing  DU Yong 

Cite this article as: Feng X, Feng GL, Liu Y, et al. Compared study on the efficacy and safety of MR and CT guided percutaneous VX2 hepatic para-vascular tumor model in rabbits[J]. Chin J Magn Reson Imaging, 2022, 13(4): 84-88. DOI:10.12015/issn.1674-8034.2022.04.015.


[Abstract] Objective To compare the efficacy and safety of 1.5 T closed magnetic resonance (MR) and computed tomography (CT) guided VX2 hepatic para-vascular tumor model in rabbits.Materials and Methods Sixty New Zealand white rabbits were randomly and equally divided into MR-guided group (n=30) and CT-guided group (n=30). Rabbit VX2 tumor fragments was implanted beside the rabbit hepatic great vessels under MR and CT-guidance in the MR and CT group respective, to evaluate the success rate of tumor model establishment, puncture needle pseudopacity/artifact and vascular development around the needle tip, operation time and safety.Results The success rate of MR-guided modeling was 96.7%, only 1 rabbit had needle metastasis, the success rate of CT-guided modeling was 80.0%, 2 rabbits had needle metastasis, 3 rabbits had metastases in other parts of the liver, and 1 had unknown cause of death. The differences in success rate of tumor model establishment between the two groups was statistically significant (P=0.044). The fold number of artifacts at T1 weighted imaging (T1WI) was 7.26±0.38 for the 20 G coaxial puncture needle in the MR-guided group and 2.51±0.57 for the 20 G coaxial puncture needle in the CT-guided group, and the difference was statistically significant (P<0.01), but 13 rabbits (43.3%) in the CT-guided group showed star-shaped hypodense artifacts would appear around the needle tip, which interfered with intrahepatic vascular display, and the difference was statistically significant (χ2=8.523, P<0.01). The operation time was longer in the MR-guided group than in the CT-guided group (13.32±2.45) min in the MR-guided group vs. (8.42±1.46) min in the CT-guided group; P<0.001). A small amount of ascites occurred in 2 patients (6.67%) in the CT-guided group. No serious complications such as liver abscess, jaundice or diaphragmatic perforation were observed in either groups.Conclusions Compared with CT, MR-guided hepatic para-vascular tumor implantation in rabbits might be a more effective modeling method. Although the needle tip pseudopacity of puncture needle is large and the operation takes a long time, the vascular development around the needle tip is clear and the incidence of complications is low.
[Keywords] magnetic resonance imaging;computed tomography;hepatic para-vascular tumor model;rabbit VX2 tumor;success rate of tumor model establishment;safety

FENG Xu   FENG Guiling   LIU Yan   SUN Baijintao   LI Bing   DU Yong*  

Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China

Du Y, E-mail: duyong@nsmc.edu.cn

Conflicts of interest   None.

Received  2021-08-16
Accepted  2022-03-21
DOI: 10.12015/issn.1674-8034.2022.04.015
Cite this article as: Feng X, Feng GL, Liu Y, et al. Compared study on the efficacy and safety of MR and CT guided percutaneous VX2 hepatic para-vascular tumor model in rabbits[J]. Chin J Magn Reson Imaging, 2022, 13(4): 84-88.DOI:10.12015/issn.1674-8034.2022.04.015

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