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Original Article
Study on diffusion kurtosis imaging of the caput nuclei caudate in children with autism spectrum disorder
SUN Yongbing  ZHAO Xin  LU Lin  XING Qingna  HE Xiongpeng  ZHANG Xiaoan 

Cite this article as: Sun YB, Zhao X, Lu L, et al. Study on diffusion kurtosis imaging of the caput nuclei caudate in children with autism spectrum disorder[J]. Chin J Magn Reson Imaging, 2022, 13(4): 69-74. DOI:10.12015/issn.1674-8034.2022.04.012.


[Abstract] Objective To investigate the clinical value of diffusional kurtosis imaging (DKI) in evaluating caput nuclei caudate changes in children with autism spectrum disorder (ASD) accompanied by language impairment.Materials and Methods A total of 34 children with ASD were collected as a case group and 30 healthy children in the same period as a control group. The independent sample t-test was used to analyze the differences in brain volume between the two groups. The DKI parameters of bilateral and right/left (R0) caudate nuclei in the two groups showed anisotropy fraction, mean diffusivity coefficient, axial diffusivity (Da), radial diffusivity (Dr), mean kurtosis (Mk), axial kurtosis, radial kurtosis (Kr) was used to analyze the relationship between DKI parameters of caudate nucleus and communication, language comprehension, and language expression scores by using Spearman correlation analysis.Results Compared with the control group, an increase in white matter volume and gray matter volume of the ASD group (P<0.05), decreased in the scores of communication, language comprehension, and language expression (P<0.05). The R0-Da value (P=0.049), the Kr value of the left caput nuclei caudat, and the Mk value of the left caput nuclei caudate in the ASD group were greater than those in the control group, and the R0-Mk value less than the control group (P all<0.05); In the control group, the left caput nuclei caudate Kr was negatively correlated with language comprehension scores (r=-0.514, P=0.004), and the left caput nuclei caudate Mk values were negatively correlated with language comprehension and language expression scores (r=-0.701, P<0.001), (r=-0.614, P<0.001), the R0-Mk values are positively correlated with language comprehension and language expression scores (r=0.481, P=0.007), (r=0.410, P=0.025 ), there was no correlation between the bilateral caput nuclei caudate and R0-DKI characteristic values and language scores of children in the ASD group (P>0.05).Conclusions DKI can be used to evaluate caudate head abnormalities in children with ASD, whose lateralization affects normal language expression.
[Keywords] autism spectrum disorder;diffusion kurtosis imaging;caput nuclei caudate;language lateralization;Psychoeducational Profile (Third Edition)

SUN Yongbing1, 2   ZHAO Xin1, 2   LU Lin1, 2   XING Qingna1, 2   HE Xiongpeng1, 2   ZHANG Xiaoan1, 2*  

1 Department of Radiology, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

2 Institute of Neuroscience, Zhengzhou University, Zhengzhou 450052, China

Zhang XA, E-mail: zxa@zzu.edu.cn

Conflicts of interest   None.

Received  2021-12-25
Accepted  2022-03-25
DOI: 10.12015/issn.1674-8034.2022.04.012
Cite this article as: Sun YB, Zhao X, Lu L, et al. Study on diffusion kurtosis imaging of the caput nuclei caudate in children with autism spectrum disorder[J]. Chin J Magn Reson Imaging, 2022, 13(4): 69-74.DOI:10.12015/issn.1674-8034.2022.04.012

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