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Clinical Article
Differential diagnosis of cerebral alveolar echinococcosis and brain metastases based on MRI perfusion weighted imaging and support vector machine
Nuerbiyemu•Abulikemu   YANG Jing  LIU Jundi  GAO Xin  WANG Gang  ZHAO Jingjing  ZHANG Yafei  JI Sihui  JIANG Chunhui  DING Shuang  WANG Yunling  LIU Wenya  JIA Wenxiao  WANG Jian 

Cite this article as: Abulikemu N, Yang J, Liu Jd, et al. Differential diagnosis of cerebral alveolar echinococcosis and brain metastases based on MRI perfusion weighted imaging and support vector machine[J]. Chin J Magn Reson Imaging, 2022, 13(4): 26-31. DOI:10.12015/issn.1674-8034.2022.04.005.

[Abstract] Objective To investigate the efficacy of MRI perfusion weighted imaging (PWI) and support vector machine (SVM) in the differential diagnosis of cerebral alveolar echinococcosis (CAE) and brain metastases (BMT).Materials and Methods The records of patients who pathologically or clinically diagnosed with CAE (15 patients) and BMT (15 patients) were reviewed retrospectively. The perfusion parameters (cerebral blood flow, cerebral blood volume, mean transit time and time to peak) of solid area, perilesion edema and contralateral relative normal area in both lesions were measured and used for evaluation of CAE and BMT. Based on perfusion parameters, SVM and other classifiers were used to identify two diseases.Results In the diagnosis of CAE/BMT, rCBF and rCBV of solid area achieved area under curve (AUC) of 0.739/0.960 and 0.710/0.913. The diagnostic efficiency of rCBF and rCBV in solid area was higher than that of MTT and TTP; The rCBF, rCBV value of CAE solid area were significantly lower than that of BMT and TTP value was significantly higher (P<0.01). The rCBF, rCBV value of CAE prelesion edema were significantly lower than that of BMT (P<0.01); Based on the perfusion parameters of lesion solid area, the use of SVM classifier can improve the discrimination accuracy.Conclusions PWI can provide an objective basis for the differential diagnosis of CAE and BMT. SVM classifier can enhance the accuracy of PWI in differentiation of these two diseases.
[Keywords] cerebral alveolar echinococcosis;brain metastases;magnetic resonance imaging;perfusion weighted imaging;support vector machine

Nuerbiyemu•Abulikemu 1   YANG Jing1, 2   LIU Jundi1   GAO Xin1   WANG Gang1   ZHAO Jingjing1   ZHANG Yafei3   JI Sihui3   JIANG Chunhui1   DING Shuang1   WANG Yunling1   LIU Wenya1   JIA Wenxiao1   WANG Jian1*  

1 Imaging Center, Xinjiang Medical University First Affiliated Hospital, Urumqi 830000, China

2 Department of Radiology, Beilun Branch, Zhejiang University School of Medicine First Affiliated Hospital, Ningbo 315800, China

3 Shanghai University School of Computer Engineering and Science, Shanghai 200444, China

Wang J, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS Key R&D Program of Xinjiang Uygur Autonomous Region (No.2016B03052).
Received  2021-10-29
Accepted  2022-03-21
DOI: 10.12015/issn.1674-8034.2022.04.005
Cite this article as: Abulikemu N, Yang J, Liu Jd, et al. Differential diagnosis of cerebral alveolar echinococcosis and brain metastases based on MRI perfusion weighted imaging and support vector machine[J]. Chin J Magn Reson Imaging, 2022, 13(4): 26-31. DOI:10.12015/issn.1674-8034.2022.04.005.

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