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Clinical Article
The diagnostic value of 18F-FDG PET/MR for cerebral tumefactive demyelinating lesions
WANG Kai  ZHANG Shu  QIAO Zhen  WU Tong  FAN Di  CHEN Qian  AI Lin 

Cite this article as: Wang K, Zhang S, Qiao Z, et al. The diagnostic value of 18F-FDG PET/MR for cerebral tumefactive demyelinating lesions[J]. Chin J Magn Reson Imaging, 2022, 13(4): 20-25. DOI:10.12015/issn.1674-8034.2022.04.004.

[Abstract] Objective To investigate the diagnostic value of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/MR multimodal imaging in tumefactive demyelinating diseases (TDL).Materials and Methods A total of 39 patients with suspected TDL from November 2019 to November 2021 were collected retrospectively, including their clinical information and multimodal PET/MR images. The imaging parameters of all 39 patients were measured by drawing the region of interest on the imaging workstation, including standard uptake value (SUV), lesion metabolic volume, total glycolysis, cerebral blood flow, cerebral blood volume, and ADC. The diagnostic efficacy of each image index was calculated by receiver operating characteristic (ROC) curve; moreover, the image indexes significantly associated with diagnostic performance were screened by univariant and multivariant logistic analysis, and then, these indexes were combined to generate the integrated diagnostic efficacy.Results SUVmax and SUVmean in TDL group were significantly higher than those in non-TDL group (13.65±2.31 vs. 10.03±1.96, P=0.028; 8.30±0.58 vs. 6.25±1.53, P=0.023). ACDmean in TDL group was higher than that in non-TDL group (1.10±0.13 vs. 0.86±0.51), and the difference was statistically significant (P=0.013). ROC analysis showed that the area under curve (AUC) of SUVmax, SUVmean and ADCmean were [0.920, 95% confidence interval (CI): 0.738-1.102; 0.940, 95% CI: 0.791-1.089;0.960, 95% CI: 0.843-1.077, respectively, P<0.001]. The AUC of the integrated diagnostic index (SUVmax + SUVmean + ADCmean) was 0.973, and the 95% CI: 0.886-1.023 (P<0.001).Conclusions 18F-FDG PET/MR multimodal imaging has a degree of value in clinical diagnosis and differential diagnosis of TDL.
[Keywords] tumefactive demyelinating lesions;fluorodeoxyglucose;positron emission tomography;magnetic resonance imaging;cerebral tumor

WANG Kai   ZHANG Shu   QIAO Zhen   WU Tong   FAN Di   CHEN Qian   AI Lin*  

Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

Ai L, E-mail:

Conflicts of interest   None.

Received  2021-12-07
Accepted  2022-03-23
DOI: 10.12015/issn.1674-8034.2022.04.004
Cite this article as: Wang K, Zhang S, Qiao Z, et al. The diagnostic value of 18F-FDG PET/MR for cerebral tumefactive demyelinating lesions[J]. Chin J Magn Reson Imaging, 2022, 13(4): 20-25.DOI:10.12015/issn.1674-8034.2022.04.004

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