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Clinical Article
The changes of functional connectivity on hemispheric level in depression patients with suicidal ideation: A functional magnetic resonance imaging study
JIANG Yu  CHENG Jingliang  CHEN Yuan  ZHENG Ruiping  HAN Shaoqiang  ZHOU Bingqian  ZHANG Yong  LI Shuying 

Cite this article as: Jiang Y, Cheng JL, Chen Y, et al. The changes of functional connectivity on hemispheric level in depression patients with suicidal ideation: A functional magnetic resonance imaging study[J]. Chin J Magn Reson Imaging, 2022, 13(4): 1-4, 14. DOI:10.12015/issn.1674-8034.2022.04.001.


[Abstract] Objective The functional connectivity density (FCD) method was used to explore the changes of inter- and intrahemispheric functional connectivity patterns in first-episode depression patients with suicidal ideation.Materials and Methods Thirty depression patients with suicidal ideation (SI group), 28 depression patients without suicidal ideation (NSI group) and 30 healthy controls (HC group) participated in this study. Hamilton Depression scale 24-items and Beck Scale for Suicide Ideation-Chinese version were performed. All subjects underwent functional magnetic resonance imaging. The inter- and intrahemispheric FCD were calculated. Correlation analysis was performed between abnormal FCD values of SI group and clinical psychological scales.Results Compared with NSI group and HC group, the interhemispheric FCD values decreased in bilateral medial prefrontal cortex in SI group. Compared with HC group, SI group and NSI group showed increased interhemispheric FCD values in bilateral postcentral gyrus, increased intrahemispheric FCD values in right postcentral gyrus and inferior parietal lobule, and decreased intrahemispheric FCD values in bilateral medial prefrontal cortex. Compared with HC group, NSI group showed decreased intrahemispheric FCD values in left anterior cingulate gyrus. The abnormal FCD values of SI group were not correlated with clinical psychological scales (P>0.05).Conclusions The abnormalities of inter- and intrahemispheric FCD in depression patients with suicidal ideation can reflect the changes of functional connectivity on hemispheric level, which is helpful to better understand the interaction between hemispheres of depression patients with suicidal ideation.
[Keywords] depression;suicidal ideation;functional connectivity density;interhemisphere;intrahemisphere;functional magnetic resonance imaging

JIANG Yu1   CHENG Jingliang1*   CHEN Yuan1   ZHENG Ruiping1   HAN Shaoqiang1   ZHOU Bingqian1   ZHANG Yong1   LI Shuying2  

1 Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

2 Department of Psychiatry, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

Cheng JL, E-mail: fccchengjl@zzu.edu.cn

Conflicts of interest   None.

Received  2021-11-08
Accepted  2022-03-21
DOI: 10.12015/issn.1674-8034.2022.04.001
Cite this article as: Jiang Y, Cheng JL, Chen Y, et al. The changes of functional connectivity on hemispheric level in depression patients with suicidal ideation: A functional magnetic resonance imaging study[J]. Chin J Magn Reson Imaging, 2022, 13(4): 1-4, 14.DOI:10.12015/issn.1674-8034.2022.04.001

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