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Study on the correlation between APT and mDixon-Quant in the right renal cortex and medulla of patients with chronic kidney disease
WANG Yue  LIU Ailian  JU Ye  DU Changyu  JIANG Haoyang  QI Lingli  BU Xinmiao  HU Wenjun  WANG Nan  WANG Jiazheng 

Cite this article as: Wang Y, Liu AL, Ju Y, et al. Study on the correlation between APT and mDixon-Quant in the right renal cortex and medulla of patients with chronic kidney disease[J]. Chin J Magn Reson Imaging, 2022, 13(3): 71-75. DOI:10.12015/issn.1674-8034.2022.03.014.

[Abstract] Objective To explore the correlation between amide proton transfer (APT) value of right renal cortex and medulla and R2* value and fat fraction (FF) value of mDixon-Quant sequence in patients with chronic kidney disease (CKD).Materials and Methods From Aug 2019 to Oct 2020, 30 patients with CKD (15 females and 15 males) who had undergone magnetic resonance examination on a 3.0 T MR scanner (Ingenia CX, Philips, Poland) were enrolled. They were divided into mild renal damage group (14 cases) and severe renal damage group (16 cases) according to estimation of glomerular filtration rate (eGFR), and 22 healthy volunteers were enrolled as control group. Import all the original images into ISP workstation to generate pseudo-color images. Select three positions from the upper, middle and lower parts of kidney, then place ROIs in cortex and medulla, with an area of about 10-20 mm2, avoiding renal sinus, great vessels and perirenal tissues. SPSS 26.0 was used for statistical analysis of the data. When the data did not conform to normal distribution, Spearman test was used to test the correlation between APT values of cortex and medulla and R2*, FF values of each group. P<0.05 was statistically significant.Results There was a positive correlation between APT and FF values in the cortex of patients with severe renal impairment (P<0.05). There was no correlation between medullary APT values and R2* values. APT values of cortex or medulla had no correlation with R2* and FF values in healthy volunteers and patients with mild renal impairment.Conclusions APT values in renal cortex of patients with severe renal impairment due to CKD is positively correlated with FF values of mDixon-Quant sequence, which can reflect the relationship among protein metabolism, acid-base environment and lipid deposition in renal tissue in different views, which had a potential clinical value of assessing the degree of renal damage in CKD.
[Keywords] amide proton transfer;mDixon-Quant;chronic kidney disease;R2*;fat fraction;renal damage;correlation

WANG Yue1, 2   LIU Ailian1, 2*   JU Ye1, 2   DU Changyu3   JIANG Haoyang3   QI Lingli3   BU Xinmiao1, 2   HU Wenjun1, 2   WANG Nan1, 2   WANG Jiazheng4  

1 Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

2 Dalian Medical Imaging Artificial Intelligence Engineering Technology Research Center, Dalian 116011, China

3 Dalian Medical University, Dalian 116044, China

4 Philips Healthcare, Shanghai 200040, China

Liu AL, E-mail:

Conflicts of interest   None.

Received  2021-07-30
Accepted  2022-03-01
DOI: 10.12015/issn.1674-8034.2022.03.014
Cite this article as: Wang Y, Liu AL, Ju Y, et al. Study on the correlation between APT and mDixon-Quant in the right renal cortex and medulla of patients with chronic kidney disease[J]. Chin J Magn Reson Imaging, 2022, 13(3): 71-75.DOI:10.12015/issn.1674-8034.2022.03.014

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