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The value of T1 mapping in clinical staging of nasopharyngeal carcinoma and its correlation with EGFR and Ki-67 index
DENG Lingda  GUO Baoliang  DU Yongxing  HU Qiugen 

Cite this article as: Deng LD, Guo BL, Du YX, et al. The value of T1 mapping in clinical staging of nasopharyngeal carcinoma and its correlation with EGFR and Ki-67 index[J]. Chin J Magn Reson Imaging, 2022, 13(3): 66-70. DOI:10.12015/issn.1674-8034.2022.03.013.


[Abstract] Objective To explore the correlation between T1 mapping, epidermal growth factor receptor (EGFR) and Ki-67 index and its value in clinical staging of nasopharyngeal carcinoma (NPC).Materials and Methods Forty-eight newly diagnosed NPC patients were analyzed. All patients underwent nasopharyngeal and neck MRI routine plain scans, dynamic enhanced scans and T1 mapping sequence scans. Pre-enhancement relaxation time (T1pre), post-enhancement relaxation time (T1post), the difference relaxation time of the tumor area before and after enhancement (ΔT1), pre-enhancement relaxation time between tumor area and the sternocleidomastoid muscle area at C3 level (ΔT1preS), post-enhancement relaxation time between tumor area and the muscle area (ΔT1postS) were obtained. T, N and clinical stages were divided into two groups: low-stage group: 19 cases of clinical stage Ⅰ+Ⅱ, 38 cases of T stage T1+T2, 18 cases of N stage N0+N1; high-stage group: 29 cases of clinical stage Ⅲ+Ⅳ, 10 cases of T stage T3+T4, 30 cases of N stage N2+N3. The T1 values between the high and low stage groups of NPC were tested by two independent samples, and the receiver operating characteristic (ROC) curve of the subjects was drawn to analyze the diagnostic efficiency. Pearson analysis was used to analyze the T1 values and Ki-67 index. Spearman correlation analysis was used to analyze the T1 values and EGFR.Results T1pre, ΔT1 and ΔT1preS in the high-stage group were higher than those in the low-stage group. T1pre, ΔT1pre and ΔT1preS were significantly correlated with clinical and N stage (P<0.05), but there was no significant difference between ΔT1preS and T stage (P=0.197). T1post and ΔT1postS had no significance difference in the staging of NPC (P>0.05). T1pre had the highest AUC for clinical stage and N stage (0.927, 0.913, P<0.05). T1pre was moderately positively correlated with EGFR and Ki-67 index (r=0.61, 0.54, P<0.05).Conclusions T1 mapping has a good correlation with clinical staging of NPC, EGFR and Ki-67 index. It can noninvasively evaluate the invasiveness and proliferation potential of tumor tissue, which is conducive to the formulation of individualized treatment plan and reduce the risk of tumor recurrence and metastasis.
[Keywords] magnetic resonance imaging;nasopharyngeal carcinoma;staging;medical prognosis;T1 mapping;Ki-67;epidermal growth factor receptor

DENG Lingda   GUO Baoliang   DU Yongxing   HU Qiugen*  

Department of Radiology, Shunde Hospital of Southern Medical University, Foshan 528306, China

Hu QG, E-mail: Hu6009@163.com

Conflicts of interest   None.

Received  2021-12-14
Accepted  2022-03-04
DOI: 10.12015/issn.1674-8034.2022.03.013
Cite this article as: Deng LD, Guo BL, Du YX, et al. The value of T1 mapping in clinical staging of nasopharyngeal carcinoma and its correlation with EGFR and Ki-67 index[J]. Chin J Magn Reson Imaging, 2022, 13(3): 66-70.DOI:10.12015/issn.1674-8034.2022.03.013

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