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The functional connectivity of default mode network and hippocampus in Alzheimer's disease: A Meta-analysis based on SDM
LU Guanqin  ZHANG Shouzi  LI Rui 

Cite this article as: Lu GQ, Zhang SZ, Li R. The functional connectivity of default mode network and hippocampus in Alzheimer's disease: A Meta-analysis based on SDM[J]. Chin J Magn Reson Imaging, 2022, 13(3): 54-60. DOI:10.12015/issn.1674-8034.2022.03.011.

[Abstract] Objective Many researches have indicated that the default-mode network (DMN) and hippocampus were vulnerable to Alzheimer's disease (AD). However, the changes in resting-state functional connectivity (rsFC) patterns of the two systems vary across the progression of AD. We aimed to use meta analysis to explore rsFC changes of AD and mild cognitive impairment (MCI) based on the DMN and hippocampus as seeds.Materials and Methods A standardized meta analysis procedure was adopted to systematically review articles from PubMed and Web of Science. A total of 12 seed-based whole-brain voxel-wise rsFC studies were finally entered into meta analysis by using signed differential mapping (SDM).Results Compared with healthy controls (HC), we found AD show significantly decreased rsFC in the medial prefrontal cortex (MPFC) by using the hippocampus as the seed region. Using DMN regions as the seed, we found AD show decreased rsFC in the MPFC, rolandic operculum, hippocampus and parahippocampus; while MCI show decreased rsFC in right posterior cingulate cortex (PCC), also with increased connectivity in the right precentral gyrus.Conclusions Reduced rsFC between the hippocampus and MPFC of anterior DMN is an important imaging feature for AD, while MCI mostly impairs the connectivity of the PCC in the posterior DMN and shows compensatory enhancement in the precentral gyrus (sensorimotor area). The results clarified the different rsFC patterns of DMN and hippocampus alterations in AD and MCI, and provided imaging reference for the recognition of AD and the evaluation of intervention effect.
[Keywords] Alzheimer's disease;mild cognitive impairment;default-mode network;hippocampus;resting-state functional connectivity;Meta-analysis

LU Guanqin1, 2   ZHANG Shouzi3   LI Rui1, 2*  

1 CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing 100101

2 Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049

3 Beijing Geriatric Hospital, Beijing 100095

Li R, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 61673374, 62177004).
Received  2021-11-08
Accepted  2022-02-18
DOI: 10.12015/issn.1674-8034.2022.03.011
Cite this article as: Lu GQ, Zhang SZ, Li R. The functional connectivity of default mode network and hippocampus in Alzheimer's disease: A Meta-analysis based on SDM[J]. Chin J Magn Reson Imaging, 2022, 13(3): 54-60. DOI:10.12015/issn.1674-8034.2022.03.011.

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