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Research progress in brain functional changes in PTSD patients
LIU Huaqiong  BA Chenghui  GAO Wenxin  JIANG Xingyue  DI Ningning  XING Chengyan  XU Chang 

Cite this article as: Liu HQ, Ba CH, Gao WX, et al. Research progress in brain functional changes in PTSD patients[J]. Chin J Magn Reson Imaging, 2022, 13(2): 120-122, 126. DOI:10.12015/issn.1674-8034.2022.02.029.

[Abstract] Post-traumatic stress disorder (PTSD) is a disorder sequelae of changes in their mental state after encountering or fighting major stress. Early explored by military psychiatrists and psychoanalysts, PTSD was a public health issue that attracted widespread social concern. In recent years, a series of public health emergencies around the world, such as the popular SARS in 2013 and novel coronavirus (COVID-19) began in the end of 2019, the outbreak of these events led to a series of psychological problems in some patients and medical workers, and even PTSD, makes PTSD a disease research hotspot, understand brain function changes in PTSD patients to prevent people's mental illness and actively treat patients are of great help. So this paper provides a review of the recent research progress on functional magnetic resonance imaging (fMRI) on changes in brain function in PTSD patients to enhance public mental health recovery in response to the persistence of a series of public health emergencies.
[Keywords] post-traumatic stress disorder;cognitive impairment;functional magnetic resonance imaging;blood oxygen level dependent

LIU Huaqiong   BA Chenghui   GAO Wenxin   JIANG Xingyue   DI Ningning   XING Chengyan   XU Chang*  

Department of Radiology, Binzhou Medical University Hospital, Binzhou 256603, China

Xu Chang, E-mail:

Conflicts of interest   None.

Received  2021-09-28
Accepted  2021-12-28
DOI: 10.12015/issn.1674-8034.2022.02.029
Cite this article as: Liu HQ, Ba CH, Gao WX, et al. Research progress in brain functional changes in PTSD patients[J]. Chin J Magn Reson Imaging, 2022, 13(2): 120-122, 126.DOI:10.12015/issn.1674-8034.2022.02.029

Kamiya K, Abe O. Imaging of Posttraumatic Stress Disorder[J]. Neuroimaging Clin N Am, 2020, 30(1): 115-123. DOI: 10.1016/j.nic.2019.09.010.
Kim SG. Biophysics of BOLD fMRI investigated with animal models[J]. J Magn Reson, 2018, 292: 82-89. DOI: 10.1016/j.jmr.2018.04.006.
Zhang XP, Bai Y, Wang MY, et al. Research progress of DWI-MRI and BOLD-fMRI in visual pathway diseases[J]. Chin J Magn Reson Imaging, 2021, 12(4): 115-117. DOI: 10.12015/issn.1674-8034.2021.04.029.
Fukuda M, Poplawsky AJ, Kim SG. Time-dependent spatial specificity of high-resolution fMRI: insights into mesoscopic neurovascular coupling[J]. Philos Trans R Soc Lond B Biol Sci, 2021, 376(1815): 20190623. DOI: 10.1098/rstb.2019.0623.
Neria Y. Functional Neuroimaging in PTSD: From Discovery of Underlying Mechanisms to Addressing Diagnostic Heterogeneity[J]. Am J Psychiatry, 2021, 178(2): 128-135. DOI: 10.1176/appi.ajp.2020.20121727.
Nisar S, Bhat AA, Hashem S, et al. Genetic and Neuroimaging Approaches to Understanding Post-Traumatic Stress Disorder[J]. Int J Mol Sci, 2020, 21(12): 4503. DOI: 10.3390/ijms21124503.
Cook MJ, Gardner AJ, Wojtowicz M, et al. Task-related functional magnetic resonance imaging activations in patients with acute and subacute mild traumatic brain injury: A coordinate-based meta-analysis[J]. Neuroimage Clin, 2020, 25: 102129. DOI: 10.1016/j.nicl.2019.102129.
Gonzalez-Castillo J, Kam JWY, Hoy CW, et al. How to Interpret Resting-State fMRI: Ask Your Participants[J]. J Neurosci, 2021, 41(6): 1130-1141. DOI: 10.1523/JNEUROSCI.1786-20.2020.
Sadraee A, Paulus M, Ekhtiari H. fMRI as an outcome measure in clinical trials: A systematic review in[J]. Brain Behav, 2021, 11(5): e02089. DOI: 10.1002/brb3.2089.
Giorgi G, Lecca LI, Alessio F, et al. COVID-19-Related Mental Health Effects in the Workplace: A Narrative Review[J]. Int J Environ Res Public Health, 2020, 17(21): 7857. DOI: 10.3390/ijerph17217857.
Manthey A, Sierk A, Brakemeier EL, et al. Does trauma-focused psychotherapy change the brain? A systematic review of neural correlates of therapeutic gains in PTSD[J]. Eur J Psychotraumatol, 2021, 12(1): 1929025. DOI: 10.1080/20008198.2021.1929025.
Kunimatsu A, Yasaka K, Akai H, et al. MRI findings in posttraumatic stress disorder[J]. J Magn Reson Imaging, 2020, 52(2): 380-396. DOI: 10.1002/jmri.26929.
Ross MC, Cisler JM. Altered large-scale functional brain organization in posttraumatic stress disorder: A comprehensive review of univariate and network-level neurocircuitry models of PTSD[J]. Neuroimage Clin, 2020, 27: 102319. DOI: 10.1016/j.nicl.2020.102319.
Sierk A, Manthey A, Brakemeier EL, et al. The dissociative subtype of posttraumatic stress disorder is associated with subcortical white matter network alterations[J]. Brain Imaging Behav, 2021, 15(2): 643-655. DOI: 10.1007/s11682-020-00274-x.
Zhang G, Zhang H, Li X, et al. Functional Alteration of the DMN by Learned Regulation of the PCC Using Real-Time fMRI[J]. IEEE Trans Neural Syst Rehabil Eng, 2013, 21(4): 595-606. DOI: 10.1109/TNSRE.2012.2221480.
Lanius RA, Terpou BA, McKinnon MC. The sense of self in the aftermath of trauma: lessons from the default mode network in posttraumatic stress disorder[J]. Eur J Psychotraumatol, 2020, 11(1): 1807703. DOI: 10.1080/20008198.2020.1807703.
Dossi G, Delvecchio G,Prunas C,et al. Neural Bases of Cognitive Impairments in Post-Traumatic Stress Disorders: A Mini-Review of Functional Magnetic Resonance Imaging Findings[J]. Front Psychiatry, 2020, 11: 176. DOI: 10.3389/fpsyt.2020.00176.
Joshi SA, Duval ER, Kubat B, et al. A review of hippocampal activation in post-traumatic stress disorder[J]. Psychophysiology, 2020, 57(1): e13357. DOI: 10.1111/psyp.13357.
Szeszko PR, Yehuda R. Magnetic Resonance Imaging Predictors of Psychotherapy Treatment Response in Post-traumatic Stress Disorder: A Role for the Salience Network[J]. Psychiatry Res, 2019, 277: 52-57. DOI: 10.1016/j.psychres.2019.02.005.
Nicholson AA, Ros T, Densmore M, et al. A randomized, controlled trial of alpha-rhythm EEG neurofeedback in posttraumatic stress disorder: A preliminary investigation showing evidence of decreased PTSD symptoms and restored default mode and salience network connectivity using fMRI[J]. Neuroimage Clin, 2020, 28: 102490. DOI: 10.1016/j.nicl.2020.102490.
Asarnow LD, Manber R. Cognitive-Behavioral Therapy for Insomnia in Depression[J]. Sleep Med Clin, 2019, 14(2): 177-184. DOI: 10.1016/j.jsmc.2019.01.009.
Thomas FC, Puente-Duran S, Mutschler C, et al. Trauma-focused cognitive behavioral therapy for children and youth in low and middle-income countries: A systematic review[J]. Child Adolesc Ment Health, 2020, 10.1111/camh.12435. DOI: 10.1111/camh.12435.
Thomaes K, Dorrepaal E, Draijer N, et al. Treatment effects on insular and anterior cingulate cortex activation during classic and emotional Stroop interference in child abuse-related complex post-traumatic stress disorder[J]. Psychol Med, 2012, 42(11): 2337-2349. DOI: 10.1017/S0033291712000499.
Cerdá M, Tracy M, Keyes KM, et al. To Treat or to Prevent?: Reducing the Population Burden of Violence-related Post-traumatic Stress Disorder[J]. Epidemiology, 2015, 26(5): 681-689. DOI: 10.1097/EDE.0000000000000350.
Jovanovic T, Ely T, Fani N, et al. Reduced neural activation during an inhibition task is associated with impaired fear inhibition in a traumatized civilian sample[J]. Cortex, 2013, 49(7): 1884-1891. DOI: 10.1016/j.cortex.2012.08.011.
Weaver SS, Birn RM, Cisler JM. A Pilot Adaptive Neurofeedback Investigation of the Neural Mechanisms of Implicit Emotion Regulation Among Women With PTSD[J]. Front Syst Neurosci, 2020, 14: 40. DOI: 10.3389/fnsys.2020.00040.
Weis CN, Webb EK, deRoon-Cassini TA, et al. Emotion Dysregulation Following Trauma: Shared Neurocircuitry of Traumatic Brain Injury and Trauma-Related Psychiatric Disorders[J]. Biol Psychiatry, 2021, S0006-3223(21):01497-01499. DOI: 10.1016/j.biopsych.2021.07.023.
Rooij SV, Rademaker A, Kennis M, et al. Impaired right inferior frontal gyrus response to contextual cues in male veterans with PTSD during response inhibition[J]. J Psychiatry Neurosci, 2014, 39(5): 330-338. DOI: 10.1503/jpn.130223.
Rooij SV, Geuze E, Kennis M, et al. Neural Correlates of Inhibition and Contextual Cue Processing Related to Treatment Response in PTSD[J]. Neuropsychopharmacology, 2015, 40(3): 667-675. DOI: 10.1038/npp.2014.220.
Fani N, Tone EB, Phifer J, et al. Attention bias toward threat is associated with exaggerated fear expression and impaired extinction in PTSD[J]. Psychol Med, 2012, 42(3): 533-543. DOI: 10.1017/S0033291711001565.
Bremner JD, Hoffman M, Afzal N, et al. The environment contributes more than genetics to smaller hippocampal volume in Posttraumatic Stress Disorder (PTSD)[J]. J Psychiatr Res, 2021, 137: 579-588. DOI: 10.1016/j.jpsychires.2020.10.042.
Abed A, Ducourneau EG, Bouarab C, et al. Preventing and treating PTSD-like memory by trauma contextualization[J]. Nat Commun, 2020, 11(1): 4220. DOI: 10.1038/s41467-020-18002-w.
Gomes-Leal W. Adult Hippocampal Neurogenesis and Affective Disorders: New Neurons for Psychic Well-Being[J]. Front Neurosci, 2021, 15: 594448. DOI: 10.3389/fnins.2021.594448.
Bernstein EE, Brühl A, Kley H, et al. Mnemonic discrimination in treatment-seeking adults with and without PTSD[J]. Behav Res Ther, 2020, 131: 103650. DOI: 10.1016/j.brat.2020.103650.
Szeszko PR, Lehrner A, Yehuda R. Glucocorticoids and Hippocampal Structure and Function in PTSD[J]. Harv Rev Psychiatry, 2018, 26(3): 142-157. DOI: 10.1097/HRP.0000000000000188.
Mccorkle TA, Barson JR, Raghupathi R. A Role for the Amygdala in Impairments of Affective Behaviors Following Mild Traumatic Brain Injury[J]. Front Behav Neurosci, 2021, 15: 601275. DOI: 10.3389/fnbeh.2021.601275.
Bae S, Sheth C, Legarreta M, et al. Volume and shape analysis of the Hippocampus and amygdala in veterans with traumatic brain injury and posttraumatic stress disorder[J]. Brain Imaging Behav, 202014(5): 1850-1864. DOI: 10.1007/s11682-019-00127-2.
Heyn SA, Schmit C, Keding TJ, et al. Neurobehavioral correlates of impaired emotion recognition in pediatric PTSD[J]. Dev Psychopathol2021, 1-11. DOI: 10.1017/S0954579420001704.
Lee MS, Anumagalla P, Pavuluri MN. Individuals with the post-traumatic stress disorder process emotions in subcortical regions irrespective of cognitive engagement: a meta-analysis of cognitive and emotional interface[J]. Brain Imaging Behav, 2021, 15(2): 941-957. DOI: 10.1007/s11682-020-00303-9.

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