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Characteristics of blood oxygen level-dependent fMRI time-signal intensity curve in amyotrophic lateral sclerosis and nerve damage
YING Weifeng  HE Yang  CHEN Qiong  ZHANG Ying  YE Fei  SUN Xiaojia  CHEN Lijuan  YUAN Tianwen  CAO Jun 

Cite this article as: Ying WF, He Y, Chen Q, et al. Characteristics of blood oxygen level-dependent fMRI time-signal intensity curve in amyotrophic lateral sclerosis and nerve damage[J]. Chin J Magn Reson Imaging, 2022, 13(2): 79-82. DOI:10.12015/issn.1674-8034.2022.02.016.


[Abstract] Objective To analyze the type of time-signal intensity curve (TIC) of blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) fed back by motor center and sensory center in patients with amyotrophic lateral sclerosis (ALS), and the correlation of TIC fed back by the motor and sensory centers.Materials and Methods Eighteen clinically diagnosed ALS patients (ALS group) and 18 age and gender-matched healthy volunteers (control group) were selected. All subjects signed the informed consent and were right-footed. The right toe was asked to stretch dorsally and regularly, the dorsal skin of the lower part of the right lower leg was stimulated regularly using a blunt-headed bamboo stick, and brain BOLD scanning was performed to detect the feedback of motor and sensory centers. The distribution of TIC types in the highest motor and sensory feedback areas of the two groups were statistically compared. According to the TIC slope grade score, the correlation of TIC type in the highest motor and sensory feedback areas in the ALS group was analyzed by Spearman correlation analysis.Results In the highest motor feedback area of the brain, descending TIC: the ALS group>the control group (P<0.001), horizontal TIC: the ALS group<the control group (P<0.001), ascending TIC: the ALS group=the control group (P=1.00). In the highest sensory feedback area of the brain, descending TIC: the ALS group<the control group (P=0.221), horizontal TIC: the ALS group<the control group (P<0.001), ascending TIC: the ALS group>the control group (P<0.001). In the ALS group, the descending TIC in the highest motor feedback area was correlated with the ascending TIC in the highest sensory feedback area (P<0.05).Conclusions In BOLD-fMRI in ALS, descending TIC is more common in motor feedback, while ascending TIC is more common in sensory feedback. Their TIC slopes have a strong negative correlation.
[Keywords] magnetic resonance imaging;blood oxygen level-dependent;functional magnetic resonance imaging;amyotrophic lateral sclerosis

YING Weifeng1   HE Yang2*   CHEN Qiong1   ZHANG Ying1   YE Fei1   SUN Xiaojia1   CHEN Lijuan1   YUAN Tianwen2   CAO Jun2  

1 Department of Radiology, Dahua Hospital, Xuhui District, Shanghai 200237, China

2 Department of Interventional Oncology, Dahua Hospital, Xuhui District, Shanghai 200237, China

He Y, E-mail: 411434316@qq.com

Conflicts of interest   None.

Received  2021-08-13
Accepted  2021-12-28
DOI: 10.12015/issn.1674-8034.2022.02.016
Cite this article as: Ying WF, He Y, Chen Q, et al. Characteristics of blood oxygen level-dependent fMRI time-signal intensity curve in amyotrophic lateral sclerosis and nerve damage[J]. Chin J Magn Reson Imaging, 2022, 13(2): 79-82.DOI:10.12015/issn.1674-8034.2022.02.016

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