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Original Article
Study on thecerebrum metabolism in PI patients using magnetic resonance spectroscopy
SU Xiaoyan  ZHAO Lianping  XIE Yuping  FANG Yanyan  ZHANG Wenwen  ZHOU Liya  HUI Peilin  WANG Xubin 

Cite this article as: Su XY, Zhao LP, Xie YP, et al. Study on thecerebrum metabolism in PI patients using magnetic resonance spectroscopy[J]. Chin J Magn Reson Imaging, 2022, 13(2): 47-51. DOI:10.12015/issn.1674-8034.2022.02.010.

[Abstract] Objective To study the cerebrum metabolism in patients with primary insomnia (PI).Materials and Methods Proton magnetic resonance spectroscopy technology was used to detect concentrations of N-acetyl-aspartate, choline-containing compounds and creatine in the thalamus, hippocampus and putamen of 38 PI patients (PI group) and 39 healthy controls (HC group), and NAA/Cr and Cho/Cr were calculated. Polysomnography (PSG) was used to measure objective sleep parameters. Assess sleep quality by fill in the form of the Pittsburgh sleep quality index and insomnia severity index; Assess sentiment by fill in the form of State-Trait Anxiety Inventory (STAI) and Beck Depression Inventory (BDI).Results (1) Comparison of metabolite concentration: compared with the HC group, the concentration of Cr and Cho in the left thalamus of PI group increased (P=0.040, P=0.007), the concentration of Cho in the right thalamus increased (P=0.039), bilateral hippocampus and shell The metabolites in the nuclear area were not different from the control group (Pall>0.05). (2) Correlation: The NAA value of the left thalamus in PI patients is negatively correlated with total sleep time and sleep efficiency (r=-0.384, P=0.017), and NAA/Cr value is negatively correlated with REM% (r=-0.387, P=0.016); right thalamus Cho/Cr value is positively correlated with SL% (r=0.380, P=0.019), There was no significant correlation between the thalamus NAA, Cr, Cho, NAA/Cr, Cho/Cr values and the scores of each scale. The Cho value of the left hippocampus of patients with insomnia is positively correlated with ArI (r=0.348, P=0.044); the Cho value of the right hippocampus (r=-0.334, P=0.047), Cr value (r=-0.445, P=0.007) and The BDI score was negatively correlated. The NAA value of the left putamen of PI was positively correlated with N3% (r=0.340, P=0.037); The Cr value of the left putamen is positively correlated with Trait Anxiety Inventory (TAI) (r=0.447, P=0.005); the NAA/Cr value of the left putamen is correlated with N1% (r=-0.344, P=0.047), TAI score (r=-0.521, P=0.001), State Anxiety Inventory (SAI) score (r=-0.400, P=0.013) is negatively correlated; Cho/Cr on the left putamen is negatively correlated with TAI score (r=-0.527, P=0.001) and SAI score (r=-0.434, P=0.007). There was no obvious correlation between the parameters of the differences between the groups and the scores of the various scales and PSG parameters.Conclusion The metabolism of Cho and Cr in the thalamus of PI patients is impaired. Objective sleep affects the metabolism of the thalamus. The patient's mood disorder is related to the metabolism of the hippocampus and putamen.
[Keywords] primary insomnia;proton magnetic resonance spectroscopy;metabolism;thalamus;hippocampus;putamen

SU Xiaoyan1   ZHAO Lianping2   XIE Yuping1*   FANG Yanyan2   ZHANG Wenwen2   ZHOU Liya3   HUI Peilin1   WANG Xubin1  

1 Sleep Medicine Center, Gansu Province Hospital, Lanzhou 730000, China

2 Department of Radiology, Gansu Province Hospital, Lanzhou 730000, China

3 EEG Electromyography Room, Gansu Province Hospital, Lanzhou 730000, China

XieYuping, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Found (No. 81560228); Gansu Province Health Industry Scientific Research Plan(No. GSWSKY-2019-88); In-Hospital Scientific Research Fund of Gansu Provincial People's Hospital (No. 21GSSYB-25).
Received  2021-08-11
Accepted  2022-01-30
DOI: 10.12015/issn.1674-8034.2022.02.010
Cite this article as: Su XY, Zhao LP, Xie YP, et al. Study on thecerebrum metabolism in PI patients using magnetic resonance spectroscopy[J]. Chin J Magn Reson Imaging, 2022, 13(2): 47-51. DOI:10.12015/issn.1674-8034.2022.02.010.

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