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Original Article
Study on multi-voxel 1H-MRS in brain of chronic mountain sickness
BAI Xiuxiu  BAO Haihua  HE Xin 

Cite this article as: Bai XX, Bao HH, He X. Study on multi-voxel 1H-MRS in brain of chronic mountain sickness[J]. Chin J Magn Reson Imaging, 2022, 13(2): 42-46. DOI:10.12015/issn.1674-8034.2022.02.009.


[Abstract] Objective Using multi-voxel hydrogen proton magnetic resonance spectroscopy (1H-MRS) to explore the characteristics of brain metabolites in chronic mountain sickness (CMS) under long-term hypoxia, and compare the metabolites with correlations between blood parameters.Materials and Methods Seventeen male patients who were diagnosed with CMS at Qinghai University Affiliated Hospital were collected as the experimental group, with age of (53.29±9.03) years, living altitude of (3989.12±937.45) meters and hemoglobin (HGB) of (224.35±11.81) g/mL. The control group consisted of eighteen healthy volunteers with the same age, gender and living altitude as the experimental group. The living altitude was (3674.94±634.27) meters, and the HGB was (156.67±9.46) g/mL. All cases were examined by routine head MRI and multi-voxel 1H-MRS 3D chemical shift imaging technology (CSI-SLASER) with 20-channel head coil of Siemens Prisma 3.0 T MR scanner. 1H-MRS images were obtained by Syngo.via post-processing software, bilateral frontal lobe and hippocampus were selected as ROIs. The ratios of N-acetylaspartate/creatine (NAA/Cr), choline/creatine (CHo/Cr), N-acetylaspartate/choline (NAA/CHo) and lactic acid/creatine (Lac/Cr) were measured. Then the correlation between the ratio of each metabolite in bilateral frontal lobe, hippocampus and blood biochemical indexes in CMS group was analyzed.Results (1) There was no significant statistical difference in age and living altitude between the two groups (P>0.05), but the HGB, red blood cell count (RBC) and hematocrit (HCT) in the two groups were significantly higher than those in the control group, while platet (PLT) was lower than those in control group, with significant differences (P<0.01). (2) Compared with the control group, NAA/Cr and NAA/CHo in bilateral frontal lobe and bilateral hippocampus decreased, Lac/Cr increased in CMS group, which were statistically significant (P<0.05). (3) Compared with the control group, the CHo/Cr of bilateral frontal lobe and bilateral hippocampus increased (P>0.05), but there was no statistical significance between the two groups. (4) In CMS group, CHo/Cr in the right frontal lobe and left hippocampus was positively correlated with RBC, CHo/Cr in the left frontal lobe was positively correlated with HCT, Lac/Cr in the right frontal lobe and left hippocampus was positively correlated with HCT.Conclusions Under the long-term hypoxia condition of CMS, local metabolites in brain tissues are changed, neurons are damaged and anaerobic metabolism increased, and the changes of these metabolites are correlated with blood indexes to a certain extent, which can provide imaging evidence and monitoring indicators for further prevention or intervention of brain damage in CMS patients.
[Keywords] hydrogen proton magnetic resonance spectroscopy;chronic mountain sickness;brain;metabolite determination;multi-voxel

BAI Xiuxiu   BAO Haihua*   HE Xin  

Image Center of Affiliated Hospital of Qinghai University, Xining 810000, China

Bao HH, E-mail: baohelen2@sina.com

Conflicts of interest   None.

Received  2021-10-21
Accepted  2022-01-27
DOI: 10.12015/issn.1674-8034.2022.02.009
Cite this article as: Bai XX, Bao HH, He X. Study on multi-voxel 1H-MRS in brain of chronic mountain sickness[J]. Chin J Magn Reson Imaging, 2022, 13(2): 42-46.DOI:10.12015/issn.1674-8034.2022.02.009

[1]
Östberg A, Ledig C, Katila A, et al. Volume Change in Frontal Cholinergic Structures After Traumatic Brain Injury and Cognitive Outcome[J]. Front Neurol, 2020, 11: 832. DOI: 10.3389/fneur.2020.00832.
[2]
Bao HH, Li RY, He ML, et al. DTI Study on Brain Structure and Cognitive Function in Patients with Chronic Mountain Sickness[J]. Sci Rep, 2019, 9(1): 19334. DOI: 10.1038/s41598-019-55498-9.
[3]
León-Velarde F, Maggiorini M, Reeves JT, et al. Consensus statement on chronic and subacute high altitude diseases[J]. High Alt Med Biol, 2005, 6(2): 147-157. DOI: 10.1089/ham.2005.6.147.
[4]
Bailey DM, Kleger GR, Holzgraefe M, et al. Pathophysiological significance of peroxidative stress, neuronal damage and membraneperme-ability in acute mountain sickness[J]. J Appl Physiol, 2006, 96(4): 1459-1464. DOI: 10.1152/japplphysiol.00704.2003.
[5]
Berger HR, Nyman A, Morken TS, et al. Early metabolite changes after melatonin treatment in neonatal rats with hypoxic-ischemic brain injury studied by in-vivo 1H MR spectroscopy[J]. PLoS One, 2017, 12(9): e0185202. DOI: 10.1371/journal.pone.0185202.
[6]
Mirdamadi JL. Cerebellar role in Parkinson's disease[J]. J Neurophysiol, 2016, 116(3): 917-919. DOI: 10.1152/jn.01132.2015.
[7]
Zacà D, Agarwal S, Gujar SK, et al. Special considerations/technical limitations of blood-oxygen-level-dependent functional magnetic resonance imaging[J]. Neuroimaging Clin N Am, 2014, 24(4): 705-715. DOI: 10.1016/j.nic.2014.07.006.
[8]
Stovell MG, Yan JL, Sleigh A, et al. Assessing Metabolism and Injury in Acute Human Traumatic Brain Injury with Magnetic Resonance Spectroscopy: Current and Future Applications[J]. Front Neurol, 2017, 8: 426. DOI: 10.3389/fneur.2017.00426.
[9]
Tekin D, Dursun AD, Baştuğ M, et al. The effects of acute and intermittent hypoxia on the expressions of HIF-1α and VEGF in the left and right ventricles of the rabbit heart[J]. Anadolu Kardiyol Derg, 2011, 11(5): 379-385. DOI: 10.5152/akd.2011.104.
[10]
Bhoopalan SV, Huang LJ, Weiss MJ. Erythropoietin regulation of red blood cell production: from bench to bedside and back[J]. F1000Res, 2020, 9(Faculty Rev): 1153. DOI: 10.12688/f1000research.26648.1.
[11]
Baltzer PA, Dietzel M, Kaiser WA. MR-spectroscopy at 1.5 tesla and 3 tesla. Useful? A systematic review and meta-analysis[J]. Eur J Radiol, 2012, 81(Suppl 1): S6-S9. DOI: 10.1016/S0720-048X(12)70003-7.
[12]
Cheng AL, Yao R, Cao WJ, et al. The Value of 1H-MRS and MRI in Combined Methylmalonic Aciduria and Homocystinuria[J]. J Comput Assist Tomogr, 2019, 43(4): 559-562. DOI: 10.1097/RCT.0000000000000854.
[13]
Hou Y, Wang XB, Chen XR, et al. Establishment and evaluation of a simulated highaltitude hypoxic brain injury model in SD rats[J]. Mol Med Rep, 2019, 19(4): 2758-2766. DOI: 10.3892/mmr.2019.9939.
[14]
Stokes JA, Arbogast TE, Moya EA, et al. Minocycline blocks glial cell activation and ventilatory acclimatization to hypoxia[J]. J Neurophysiol, 2017, 117(4): 1625-1635. DOI: 10.1152/jn.00525.2016.
[15]
Mergenthaler P, Lindauer U, Dienel GA, et al. Sugar for the brain: the role of glucose in physiological and pathological brain function[J]. Trends Neurosci, 2013, 36(10): 587-597. DOI: 10.1016/j.tins.2013.07.001.
[16]
Vestergaard MB, Lindberg U, Aachmann-Andersen NJ, et al. Acute hypoxia increases the cerebral metabolic rate-a magnetic resonance imaging study[J]. J Cereb Blood Flow Metab, 2016, 36(6): 1046-1058. DOI: 10.1177/0271678X15606460.
[17]
Atiguli MMT. Protective effect of total flavonoids of Dracocephalum moldavica L. on chronic mountain sickness rats based on 1H-NMR metabonomics[D]. Xinjiang Med Univ, 2020. DOI: 10.27433/d.cnki.gxyku.2020.000969.
[18]
Jiang CH, Chen J, Liu FY, et al. Chronic mountain sickness in Chinese Han males who migrated to the Qinghai-Tibetan plateau: application and evaluation of diagnostic criteria for chronic mountain sickness[J].BMC Public Health,2014,14:701. DOI: 10.1186/1471-2458-14-701.
[19]
Li ZB, Liu CW, Guo J, et al. Early Warning of Acute Altitude Sickness by Physiological Variables and Noninvasive Cardiovascular Indicators[J]. Chin Med Sci J, 2020, 35(1): 13-19. DOI: 10.24920/003552.
[20]
Liu CW, Li ZB, Guo J, et al.Physiological Variables Associated with the Development of Acute Mountain Sickness[J]. Chin Med Sci J, 2019, 34(4): 263-269. DOI: 10.24920/003518.

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