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Original Article
A fMRI study of hippocampal functional connectivity changes in benign childhood epilepsy with centrotemporal spikes
MA Xueying  BAN Chao  ZHAO Pengfei  NIU Guangming  QIAO Pengfei 

Cite this article as: Ma XY, Ban C, Zhao PF, et al. A fMRI study of hippocampal functional connectivity changes in benign childhood epilepsy with centrotemporal spikes[J]. Chin J Magn Reson Imaging, 2022, 13(2): 22-25. DOI:10.12015/issn.1674-8034.2022.02.005.


[Abstract] Objective To detect the changes of functional connection between subregions of the hippocampus and the whole brain in children benign epilepsy with centrotemporal spikes (BECTS) and analyze the potential neural mechanism and clinical value.Materials and Methods The resting state blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) whole brain data of forty-four BECTS patients and thirty-five age-and sex-matched healthy controls were prospectively collected. Functional connectivity analysis method based on seed points was used to analyze the functional connection between the anterior and posterior hippocampus and the whole brain respectively.Results Compared with healthy controls, functional connectivity between the left anterior hippocampus and the right precuneus, the right inferior parietal lobule, and the left middle temporal gyrus was decreased in BECTS children (P<0.001). The functional connectivity between the right anterior hippocampus and the left middle temporal gyrus temporal pole, right parahippocampal gyrus, and right middle frontal gyrus orbital was decreased (P<0.001); The functional connectivity between the left posterior hippocampus and the left hippocampus and the right inferior parietal lobule was decreased (P<0.001); The functional connectivity between the right posterior hippocampus and the right lingual gyrus and the right parahippocampal gyrus was increased (P<0.001).Conclusions The functional connectivity between the hippocampus and the whole brain in BECTS children was changed, which had a great significance on understanding the underlying neuropathological mechanism of BECTS.
[Keywords] benign childhood epilepsy with centrotemporal spikes;hippocampus;functional connectivity;resting state;blood oxygen level dependent;functional magnetic resonance imaging

MA Xueying   BAN Chao   ZHAO Pengfei   NIU Guangming   QIAO Pengfei*  

Department of Imaging Diagnosis, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China

Qiao PF, E-mail: qpfff@126.com

Conflicts of interest   None.

Received  2021-07-12
Accepted  2021-12-28
DOI: 10.12015/issn.1674-8034.2022.02.005
Cite this article as: Ma XY, Ban C, Zhao PF, et al. A fMRI study of hippocampal functional connectivity changes in benign childhood epilepsy with centrotemporal spikes[J]. Chin J Magn Reson Imaging, 2022, 13(2): 22-25.DOI:10.12015/issn.1674-8034.2022.02.005

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