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Clinical Article
Application of MR myocardial strain technique in the diagnosis and differential diagnosis of hypertrophic cardiomyopathy
YANG Xinyao  WU Jiang  ZHU Lina  HAO Xiaoyong  LI Xuan  NIU Heng 

Cite this article as: Yang XY, Wu J, Zhu LN, et al. Application of MR myocardial strain technique in the diagnosis and differential diagnosis of hypertrophic cardiomyopathy[J]. Chin J Magn Reson Imaging, 2022, 13(2): 10-15, 21. DOI:10.12015/issn.1674-8034.2022.02.003.

[Abstract] Objective To apply cardiac magnetic resonance tissue tracking technology (CMR-TT) to quantitatively evaluate myocardial function in patients with hypertrophic cardiomyopathy (HCM) and myocardial function in patients with left ventricular hypertrophy caused by cardiac amyloidosis (CA), and to analyze the differences in myocardial strain changes.Materials and Methods Select 30 patients with hypertrophic cardiomyopathy (HCM group), 15 patients with myocardial amyloidosis (CA group), and 30 normal people as normal controls (NC group), using CMR-TT technology and CVI42 post-processing software measure conventional strain parameters such as longitudinal strain (LS), circumferential strain (CS), radial strain (RS) of the whole myocardium and segments (basal, middle, apical) and relative apical sparing of strain (RAS), and quantitatively assess the overall and local movement of the myocardium.Results The values of the strain parameters among the NC group, HCM group, and CA group decreased successively, and all three groups were statistically significant (P<0.05); in the pairwise comparison, apical circumferential strain (ACS) was not statistically significant except for the NC group and the HCM group, the rest were statistically significant (P<0.05); RASRS, RASCS, and RASLS were all statistically significant (P<0.05). The area under the ROC curve of global radial strain (GRS), global circumferential strain (GCS), global longitudinal strain (GLS), basal radial strain (BRS), basal circumferential strain (BCS), basal longitudinal strain (BLS) in the HCM group and NC group were 0.77, 0.71, 0.77, 0.90, 0.73, 0.78, respectively (P<0.05), and the area under the curve of BRS was significantly higher than other parameters. The area under the ROC curve of RASRS, RASCS and RASLS of HCM group and CA group were 0.83, 0.75, 0.71 respectively (P<0.05), which has certain value for the differential diagnosis of HCM and CA.Conclusions CMR-TT can be used to evaluate the overall and local functional movement of the heart. HCM myocardial strain is reduced, HCM basal segment strain is significantly reduced, and BRS has greater diagnostic value; CA patients' myocardial strain decreases more than HCM patients for obvious reasons, the relative apical retention mode provides a certain reference value for the differential diagnosis of the two, and the relative apical RS has the best diagnostic efficiency.
[Keywords] cardiac magnetic resonance;myocardial strain;hypertrophic cardiomyopathy;diagnosis;differential diagnosis

YANG Xinyao1   WU Jiang2*   ZHU Lina2   HAO Xiaoyong2   LI Xuan2   NIU Heng2  

1 School of Medical Imaging, Shanxi Medical University, Taiyuan 030001, China

2 Department of Magnetic Resonance, Cardiovascular Hospital of Shanxi Province, Taiyuan 030024, China

Wu J, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS Scientific Research Project of Shanxi Provincial Health Commission (No. 2020038).
Received  2021-08-01
Accepted  2022-02-07
DOI: 10.12015/issn.1674-8034.2022.02.003
Cite this article as: Yang XY, Wu J, Zhu LN, et al. Application of MR myocardial strain technique in the diagnosis and differential diagnosis of hypertrophic cardiomyopathy[J]. Chin J Magn Reson Imaging, 2022, 13(2): 10-15, 21. DOI:10.12015/issn.1674-8034.2022.02.003.

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