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Original Article
A preliminary study of cerebral blood flow perfusion based on the ASL in patients with tension type headache in the resting states
ZHANG Chengcheng  WANG Jili  WANG Yaqi  ZHANG Shuxian  XU Qinyan  SUN Tong  WANG Xizhen  SUN Xihe 

Cite this article as: Zhang CC, Wang JL, Wang YQ, et al. A preliminary study of cerebral blood flow perfusion based on the ASL in patients with tension type headache in the resting states[J]. Chin J Magn Reson Imaging, 2022, 13(1): 76-80. DOI:10.12015/issn.1674-8034.2022.01.015.


[Abstract] Objective To investigate the alteration patterns of cerebral blood flow (CBF) based on arterial spin labeling (ASL) and its correlation with the degree of pain in patients with tension type headache in the resting states.Materials and Methods: Thirty-one cases of tension-type headache patients and 33 cases of matched healthy control volunteers were collected from May 2018 to July 2019 in Affiliated Hospital of Weifang Medical University. A three-dimensional pseudo-continuous arterial spin labeling (3D-pCASL) imaging was performed to measure CBF in the resting-states. The difference of CBF between tension headache group and healthy control group was analyzed, visual analogue scale (VAS) was used to evaluate the degree of pain in TTH group, and the correlation between the brain region with altered CBF values and pain degree was evaluated in tension headache patients.Results Compared with the healthy control group, the CBF values of bilateral parahippocampal gyrus, left thalamus, left putamen, right hippocampus, left caudate nucleus, left insular lobe in TTH group increased, while the CBF values of right central posterior gyrus, right inferior frontal gyrus of insular tectum and left middle frontal gyrus decreased (P<0.05, family-wise error, FWE correction). In addition, the CBF values of left lenticular putamen, left caudate nucleus and right hippocampus were positively correlated with VAS scores (r=0.374, r=0.416, r=0.358, P<0.05), while the CBF values of right inferior frontal gyrus were negatively correlated with VAS scores (r=-0.444, P<0.05).Conclusion Tension-type headache patients had multiple brain regions with altered CBF value, which may be involved in the central pathophysiological mechanism of tension type headache.
[Keywords] tension-type headache;cerebral blood flow;arterial spin labeling;perfusion imaging;magnetic resonance imaging;the degree of pain;correlation analysis

ZHANG Chengcheng1   WANG Jili1   WANG Yaqi3   ZHANG Shuxian2*   XU Qinyan2   SUN Tong1   WANG Xizhen1   SUN Xihe1*  

1 School of Medical Imaging, Weifang Medical University, Weifang 261031, China

2 Affiliated Hospital of Weifang Medical University, Weifang 261031, China

3 Department of Medical Imaging of Weifang Hospital of Traditional Chinese Medicine, Weifang 261031, China

Zhang SX, E-mail: zhangshuxian366@126.com Sun XH, E-mail: sunxihe8130@163.com

Conflicts of interest   None.

Received  2021-07-19
Accepted  2021-11-09
DOI: 10.12015/issn.1674-8034.2022.01.015
Cite this article as: Zhang CC, Wang JL, Wang YQ, et al. A preliminary study of cerebral blood flow perfusion based on the ASL in patients with tension type headache in the resting states[J]. Chin J Magn Reson Imaging, 2022, 13(1): 76-80.DOI:10.12015/issn.1674-8034.2022.01.015

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