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Clinical Article
Study on the relationship between signal intensity parameters of liver lobes and albumin-bilirubin grades in magnetic resonance images enhanced with Gd-EOB-DTPA
LIU Guanchen  SUN Peng  TIAN Yuan  MENG Xiangge  SU Yexin  LIU Pengfei 

Cite this article as: Liu GC, Sun P, Tian Y, et al. Study on the relationship between signal intensity parameters of liver lobes and albumin-bilirubin grades in magnetic resonance images enhanced with Gd-EOB-DTPA[J]. Chin J Magn Reson Imaging, 2022, 13(1): 37-41. DOI:10.12015/issn.1674-8034.2022.01.008.


[Abstract] Objective To investigate the relationship between lobar based signal intensity parameters and Albumin - Bilirubin (ALBI) grade in patients with chronic hepatitis B-related liver cirrhosis on gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) enhanced MRI.Materials and Methods: Gd-EOB-DTPA enhanced MRI images of 62 patients with normal liver (n=15), ALBI grade 1 (n=23), ALBI grade 2 (n=18), and ALBI grade 3 (n=6) with chronic hepatitis B associated cirrhosis were analyzed. Liver parenchyma relative enhancement (LRE) and liver-to-muscle ratio (LMR) of right lobe, left medial lobe, left lateral lobe and caudate lobe were calculated, and compared between normal group and different ALBI grading groups. The relationship between LRE, LMR and ALBI grading of liver lobes in patients with chronic hepatitis B-related cirrhosis was quantitatively analyzed, and the accuracy of ALBI grade 1 and ALBI grade 2-3 were evaluated by ROC curve.Results The LRE and LMR values of each liver lobe were significantly different between the normal group and different ALBI grading groups (P<0.05). The pairings of each group showed that there was no significant difference in LRE value of each liver lobe between ALBI 2 and ALBI 3 groups (P>0.05), and there was a significant difference in LMR value of each liver lobe between any two groups (P<0.001). The LRE and LMR of each lobe of liver in patients with chronic hepatitis B-related liver cirrhosis were negatively correlated with ALBI grade (P<0.001). LRE in the right lobe of the liver had the highest accuracy in distinguishing ALBI grade 1 from ALBI grade 2-3, and the area under the receiver operating characteristic curve is 0.913.Conclusions There is a correlation between LRE and LMR based on liver lobe and ALBI grade of liver function in patients with chronic hepatitis B related cirrhosis in Gd-EOB-DTPA enhanced MRI. LRE and LMR are expected to be imaging methods to evaluate liver lobe function.
[Keywords] liver cirrhosis;magnetic resonance imaging;gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid;quantitative evaluation;liver function

LIU Guanchen   SUN Peng   TIAN Yuan   MENG Xiangge   SU Yexin   LIU Pengfei  

Department of MRI, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Liu PF, E-mail: Pfeiliu@hotmail.com

Conflicts of interest   None.

Received  2021-07-30
Accepted  2021-11-25
DOI: 10.12015/issn.1674-8034.2022.01.008
Cite this article as: Liu GC, Sun P, Tian Y, et al. Study on the relationship between signal intensity parameters of liver lobes and albumin-bilirubin grades in magnetic resonance images enhanced with Gd-EOB-DTPA[J]. Chin J Magn Reson Imaging, 2022, 13(1): 37-41.DOI:10.12015/issn.1674-8034.2022.01.008

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