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Clinical Article
Quantitative assessment of paraspinal muscle fat infiltration in early stage ankylosing spondylitis patients by using MRI IDEAL sequence
HUANG Ruibin  YANG Hongwu  SU Shuyan  CHEN Liujiang  ZHUANG Ruyao  LIU Yuan 

Cite this article as: Huang RB, Yang HW, Su SY, et al. Quantitative assessment of paraspinal muscle fat infiltration in early stage ankylosing spondylitis patients by using MRI IDEAL sequence[J]. Chin J Magn Reson Imaging, 2022, 13(1): 26-30. DOI:10.12015/issn.1674-8034.2022.01.006.


[Abstract] Objective To evaluate fat infiltration of the multifidus and erector spinal muscles of the lower waist (L3/4, L4/5 levels) of ankylosing spondylitis (AS) patients in early stage, and explore the correlation between them and clinical indicators.Materials and Methods: Using a prospective study, 40 clinically diagnosed AS patients in early stage (AS group) 41 healthy volunteers (control group) matched in age, sex, and body mass index, all subjects were evaluated using iterative decomposition of water and fat with echo asymmetric and leastsquares estimation (IDEAL) sequence examination, the fat fraction values (ƞ) of multifidus and erector muscles at the levels of L3/4 and L4/5 were measured respectively. The clinical indicators such as the course of disease, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in AS group were collected during the same period. The independent samples t test (or Mann-Whitney U test) was used to compare the quantitative data between the two groups. Spearman correlation was used to evaluate the correlation between ƞ values of multifidus, erector spinae at the levels of L3/4 and L4/5 and clinical indicators.Results The average ƞ values of erector spinae and multifidus muscles at the levels of L3/4 and L4/5 in AS group were higher than those in the control group [(0.28±0.09) vs. (0.24±0.05); (0.32±0.07) vs. (0.26±0.05); (0.31±0.07) vs. (0.28±0.06); (0.36±0.08) vs. (0.30±0.06)], the differences were statistically significant (P<0.05). The average ƞ values of erector spinae and multifidus muscles at the levels of L3/4 and L4/5 in AS group were positively correlated with the course of the disease (P<0.05), but were not significantly correlated with ESR, CRP, and BASDAI scores (P>0.05).Conclusions IDEAL sequence could be used in the quantitative analysis of fat infiltration in lower lumbar paraspinal muscles in early AS patients with good evaluation value for clinical treatment.
[Keywords] spondylitis, ankylosing;paravertebral muscle;fat infiltration;magnetic resonance imaging

HUANG Ruibin   YANG Hongwu   SU Shuyan   CHEN Liujiang   ZHUANG Ruyao*   LIU Yuan  

Department of Radiology, The First Affiliated Hospital of Shantou University Medical College, Shantou 515000, China

Zhuang RY, E-mail: SDFYzry@163.com

Conflicts of interest   None.

Received  2021-08-04
Accepted  2021-12-21
DOI: 10.12015/issn.1674-8034.2022.01.006
Cite this article as: Huang RB, Yang HW, Su SY, et al. Quantitative assessment of paraspinal muscle fat infiltration in early stage ankylosing spondylitis patients by using MRI IDEAL sequence[J]. Chin J Magn Reson Imaging, 2022, 13(1): 26-30.DOI:10.12015/issn.1674-8034.2022.01.006

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