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Clinical Article
Three-dimensional arterial spin labeling perfusion imaging shows cerebral blood flow decline in some brain regions in preschool autistic children
CHENG Zhuo  TANG Shilong  ZHANG Yun  CHEN Wushuang  DAI Chunmei  WU Lan  LIU Xianfan  HE Ling 

Cite this article as: Cheng Z, Tang SL, Zhang Y, et al. Three-dimensional arterial spin labeling perfusion imaging shows cerebral blood flow decline in some brain regions in preschool autistic children[J]. Chin J Magn Reson Imaging, 2022, 13(1): 11-14, 20. DOI:10.12015/issn.1674-8034.2022.01.003.


[Abstract] Objective To explore the feasibility of three-dimensional arterial spin labeling (3D-ASL) perfusion imaging in the brain of children with preschool autism.Materials and Meythods: Each 40 autistic children aged 2, 3, 4, 5 were selected, and 40 healthy children aged 2, 3, 4, 5 were control groups, and all children underwent routine MR and 3D-T1, 3D-ASL scans. The value of cerebral blood perfusion (CBF) was obtained by software posttreatment, compared the value of autistic children of the same age and healthy children, and found the characteristics of CBF in autistic children of all ages.Results In the 2 years old group, the CBF values of temporal lobe, hippocampus and putamen in autistic children were lower than those in healthy children; in the 3 years old group, the CBF values of frontal lobe, temporal lobe, parietal lobe, hippocampus and putamen of autistic children were lower than those of healthy children; in the 4 years old group, the CBF values of temporal lobe, frontal lobe, parietal lobe, hippocampus, putamen and caudate nucleus in autistic children were lower than those in healthy children; in the 5 years old group, the CBF values of temporal lobe, parietal lobe, hippocampus, putamen and caudate nucleus in autistic children were lower than those in healthy children.Conclusions 3D-ASL technology can reflect cerebral blood flow perfusion and more comprehensively reflect the pathological process in children with autism.
[Keywords] autism;children;three-dimensional arterial spin labeling;brain;magnetic resonance imaging

CHENG Zhuo1   TANG Shilong1*   ZHANG Yun1   CHEN Wushuang1   DAI Chunmei2   WU Lan2   LIU Xianfan2   HE Ling2  

1 Department of Radiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014

2 Chongqing Key Laboratory of Pediatrics, Chongqing 400014

Tang SL, E-mail: tangshilong66@163.com

Conflicts of interest   None.

Received  2021-06-03
Accepted  2021-12-17
DOI: 10.12015/issn.1674-8034.2022.01.003
Cite this article as: Cheng Z, Tang SL, Zhang Y, et al. Three-dimensional arterial spin labeling perfusion imaging shows cerebral blood flow decline in some brain regions in preschool autistic children[J]. Chin J Magn Reson Imaging, 2022, 13(1): 11-14, 20.DOI:10.12015/issn.1674-8034.2022.01.003

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