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Clinical Article
Characteristic analysis of DWI and HRMR-VWI in patients with symptomatic middle cerebral atherosclerotic stenosis: comparison between the young group and middle-aged and elderly group
LÜ Xia  ZHAO Jiaxin  MA Zelan  LIU Xian  LIU Guoqing 

Cite this article as: Lü X, Zhao JX, Ma ZL, et al. Characteristic analysis of DWI and HRMR-VWI in patients with symptomatic middle cerebral atherosclerotic stenosis: comparison between the young group and middle-aged and elderly group[J]. Chin J Magn Reson Imaging, 2022, 13(1): 1-5, 10. DOI:10.12015/issn.1674-8034.2022.01.001.


[Abstract] Objective To investigate the differences of the characteristics of responsible vessel wall between young and middle-aged and elderly patients with symptomatic middle cerebral atherosclerotic stenosis (sMCAS) based on high resolution magnetic resonance vessel wall imaging (HRMR-VWI).Materials and Methods: From August 2019 to April 2021,consecutive patients with ischemic stroke or transient ischemic attack caused by sMCAS were selected and divided into young group (≤45 years old) and middle-aged and elderly group (>45 years old). The mechanism of sMCAS stroke was determined according to the distribution pattern of acute cerebral infarction on DWI, including parent artery occluding penetrating artery, hypoperfusion, artery-artery embolization and multiple mechanism. The differences of risk factors between the two groups and the differences of HRMR-VWI wall characteristics of responsible vessels were analyzed, including plaque area, plaque burden, length, enhancement pattern, intraplaque bleeding, plaque distribution pattern, stenosis rate of responsible vessels, remodeling index and remodeling pattern.Results One hundred and three patients with sMCAS were included, including 30 young patients and 73 middle-aged and elderly patients. There were significant differences in hypertension and coronary heart disease between the two groups (P<0.05); there was no significant difference in the mechanism of sMCAS stroke between the two groups (P>0.05).The plaque area, plaque burden and vascular remodeling index of the middle-aged and elderly group were higher than those of the young group (P<0.05); there was no significant difference in plaque length, plaque enhancement pattern, intraplaque bleeding, plaque distribution, stenosis rate and remodeling pattern between the two groups (P>0.05).Conclusions There are differences in plaque area, plaque burden and vascular remodeling index between young and middle aged-elderly patients with sMCAS, suggesting that the pathophysiological changes of young patients with sMCAS are different, and their intervention strategies may be different from those of middle-aged and elderly patients.
[Keywords] diffusion weighted imaging;high resolution magnetic resonance vessel wall imaging;middle cerebral artery;atherosclerosis;age

LÜ Xia   ZHAO Jiaxin   MA Zelan*   LIU Xian   LIU Guoqing  

Department of Radiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China

Ma ZL, E-mail: 305131863@qq.com

Conflicts of interest   None.

Received  2021-07-16
Accepted  2021-11-10
DOI: 10.12015/issn.1674-8034.2022.01.001
Cite this article as: Lü X, Zhao JX, Ma ZL, et al. Characteristic analysis of DWI and HRMR-VWI in patients with symptomatic middle cerebral atherosclerotic stenosis: comparison between the young group and middle-aged and elderly group[J]. Chin J Magn Reson Imaging, 2022, 13(1): 1-5, 10.DOI:10.12015/issn.1674-8034.2022.01.001

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